Effects of striatal or accumbens lesions on the amphetamine-induced abolition of latent inhibition
| Autor: | Maria Konstandi, E. Kafetzopoulos |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Nucleus Accumbens/anatomy & histology/drug effects/*physiology
Male Dextroamphetamine Clinical Biochemistry Striatum Stimulus (physiology) Nucleus accumbens Toxicology Biochemistry Nucleus Accumbens Injections Behavioral Neuroscience chemistry.chemical_compound Latent inhibition Conditioning Operant/*drug effects medicine Animals Corpus Striatum/anatomy & histology/drug effects/*physiology Rats Wistar Amphetamine Ibotenic Acid Biological Psychiatry Dextroamphetamine/*pharmacology Pharmacology Ibotenic Acid/administration & dosage/pharmacology Dopaminergic Corpus Striatum Rats chemistry Conditioning Operant Psychology Neuroscience Ibotenic acid medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 44:751-754 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(93)90001-a |
| Popis: | In this study, we tested the effects of nucleus accumbens or corpus striatum lesions on the abolition of latent inhibition induced by d-amphetamine. In the latent inhibition paradigm, animals learn to ignore a repeatedly presented nonreinforced stimulus. In this paradigm, the repeated nonreinforced preexposure to a stimulus retards subsequent conditioning to that stimulus. Pharmacological manipulations that enhance the dopaminergic function (e.g., d-amphetamine) abolish this ability to ignore an irrelevant stimulus. Previous studies have revealed a major role of the nucleus accumbens in the d-amphetamine-induced abolition of latent inhibition because intraacumbens injections of the drug mimic its systemic effects. The results of this study, however, revealed a significant increase in the disruption of latent inhibition by d-amphetamine between corpus striatum-lesioned and sham-operated rats, but a marginal difference between nucleus accumbens lesioned and sham-operated rats, which had been preexposed to the stimulus. These findings indicate that the corpus striatum plays also a major role in the disruption of latent inhibition by d-amphetamine. It seems, therefore, that the nucleus accumbens and corpus striatum may represent a functionally common system regarding the expression of latent inhibition, although different experimental manipulation can favor the one structure over the other, reflecting probably their complex function. Pharmacol Biochem Behav |
| Databáze: | OpenAIRE |
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