Heterosubstituted anthracene-9,10-dione analogs. The synthesis and antitumor evaluation of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b]thiophene-4,9-diones
| Autor: | A. P. Krapcho, Miles P. Hacker, Petry Me |
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| Rok vydání: | 1990 |
| Předmět: |
Anthracene
Mitoxantrone Chemical Phenomena Stereochemistry Antineoplastic Agents Biological activity Thiophenes Naphthalenes In vitro Quinone Chemistry Mice Structure-Activity Relationship chemistry.chemical_compound chemistry In vivo Diamine Drug Discovery medicine Thiophene Animals Molecular Medicine Leukemia L1210 medicine.drug |
| Zdroj: | Journal of Medicinal Chemistry. 33:2651-2655 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00171a048 |
| Popis: | A number of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b]thiophene-4, 9-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Two of the congeners exhibited in vivo activities quite comparable to that of mitoxantrone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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