| Popis: |
Diabetes is a serious chronic metabolic disease, and it is imperative to use advanced herbal safe medicines with anti-diabetic compounds in addition to synthetic medicines for recent treatments. Rabbits were divided into 4 groups; group 1 or healthy group, group 2 or control group without medication, group 3 or experimental group with Antischemin (1:1:1) at 100 mg/kg, and group 4 or comparing group with Clopidogrel with 2.14 mg/kg orally for 5 days respectively and 5 days after a 6% Alloxan monohydrate (Sigma Chemicals, USA) solution was injected through rabbit ear IV with 60 mg/kg by Lukenes (1948); Gaulton et al (1985) method and created diabetes model developed a pathogenic disorder for diabetes. Specific parameters such as CH, TG, LDH and HDL concentration were measured on day 3, 7, 14, 21 and 28. Antishemin preparation effect of decreasing glucose by 5.36-25.9%, cholesterol by 18.3-57.1%, triglycerides by 26-35.7% and LDL by 64.1-76%, respectively and increasing HDL by 11.2-48.5%, indicating that it may related to decreasing hyper coagulation of microvasculature in organs and accelerating metabolic rate. Antishemin preparations have been shown to have a positive effect on CH, TG, LDL reduced by respectively and HDL increased during diabetes. |
