Aldosterone synthase gene regulation by angiotensin
| Autor: | Allan R. Brasier, O. Bryan Holland, Boyd K. Carr |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Aldosterone synthase
medicine.medical_specialty Angiotensin receptor Response element Gene Expression Regulation Enzymologic chemistry.chemical_compound Endocrinology Cytochrome P-450 Enzyme System Internal medicine Renin–angiotensin system medicine Tumor Cells Cultured Cytochrome P-450 CYP11B2 Humans Secretion Regulation of gene expression Angiotensin II receptor type 1 Aldosterone biology Angiotensin II Genetic Complementation Test General Medicine Adrenal Cortex Neoplasms chemistry biology.protein Steroid 11-beta-Hydroxylase |
| Zdroj: | Endocrine research. 21(1-2) |
| ISSN: | 0743-5800 |
| Popis: | Excessive aldosterone secretion in some hypertensive patients may result from abnormal aldosterone synthase (AS) gene regulation in response to changes in dietary sodium intake. We have utilized NCI-H295 cells, which exhibit stable angiotensin-induced aldosterone secretion, for transient transfections with murine AS/human growth hormone reporter constructs. An angiotensin response element increasing AS gene transcription during angiotensin stimulation appears to reside within the initial 425 nt of the murine AS promoter. We also noted the possible presence of a negatively-acting cis element between nt −425 and −1500. These studies provide an initial step toward characterizing molecular mechanisms by which angiotensin regulates AS gene transcription. |
| Databáze: | OpenAIRE |
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