Development and Evaluation of a Genetic Risk Score for Obesity
| Autor: | Avshalom Caspi, Karen Sugden, Benjamin Williams, Daniel W. Belsky, Renate Houts, Jeanette J. McCarthy, Terrie E. Moffitt |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Genome-wide association study Overweight Polymorphism Single Nucleotide Risk Assessment White People Article Body Mass Index Epidemiology Genetics medicine Humans Family Genetic Predisposition to Disease Obesity Prospective Studies Ecology Evolution Behavior and Systematics Demography business.industry Atherosclerosis medicine.disease United States Black or African American Phenotype ROC Curve Anthropology Cohort Female Metabolic syndrome medicine.symptom Risk assessment business Body mass index Genome-Wide Association Study |
| Zdroj: | Biodemography and Social Biology. 59:85-100 |
| ISSN: | 1948-5573 1948-5565 |
| DOI: | 10.1080/19485565.2013.774628 |
| Popis: | Multi-locus profiles of genetic risk, so-called "genetic risk scores," can be used to translate discoveries from genome-wide association studies into tools for population health research. We developed a genetic risk score for obesity from results of 16 published genome-wide association studies of obesity phenotypes in European-descent samples. We then evaluated this genetic risk score using data from the Atherosclerosis Risk in Communities (ARIC) cohort GWAS sample (N = 10,745, 55% female, 77% white, 23% African American). Our 32-locus GRS was a statistically significant predictor of body mass index (BMI) and obesity among ARIC whites [for BMI, r = 0.13, p1 × 10(-30); for obesity, area under the receiver operating characteristic curve (AUC) = 0.57 (95% CI 0.55-0.58)]. The GRS predicted differences in obesity risk net of demographic, geographic, and socioeconomic information. The GRS performed less well among African Americans. The genetic risk score we derived from GWAS provides a molecular measurement of genetic predisposition to elevated BMI and obesity.[Supplemental materials are available for this article. Go to the publisher's online edition of Biodemography and Social Biology for the following resource: Supplement to DevelopmentEvaluation of a Genetic Risk Score for Obesity.]. |
| Databáze: | OpenAIRE |
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