Monocyte-predominant engraftment, cytokine levels and early transplant-related complications in pediatric hematopoietic stem cell recipients
| Autor: | Francesca Barbieri, Roberto Simeone, Annalisa Marcuzzi, Davide Zanon, Lorenzo Monasta, Alberto Tommasini, Roberto Sala, Natalia Maximova, Marilena Granzotto |
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| Přispěvatelé: | Maximova, Natalia, Granzotto, Marilena, Barbieri, Francesca, Marcuzzi, Annalisa, Tommasini, Alberto, Monasta, Lorenzo, Simeone, Roberto, Zanon, Davide, Sala, Roberto |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine monocyte-predominant engraftment Radiology Nuclear Medicine and Imaging Cancer Research Transplantation Conditioning medicine.medical_treatment Hepatic Veno-Occlusive Disease Hematopoietic stem cell transplantation Defibrotide defibrotide monocyte‐predominant engraftment Monocytes 0302 clinical medicine Nuclear Medicine and Imaging cytokine Child Original Research cytokines defibrotide hematopoietic stem cell transplantation monocyte‐predominant engraftment pediatric short‐term transplant‐related complication Hematopoietic Stem Cell Transplantation Hematopoietic stem cell Prognosis surgical procedures operative medicine.anatomical_structure Cytokine Oncology 030220 oncology & carcinogenesis hematopoietic stem cell transplantation Female Radiology medicine.drug NO 03 medical and health sciences Polydeoxyribonucleotides Fibrinolytic Agents medicine Humans Radiology Nuclear Medicine and imaging Adverse effect Retrospective Studies business.industry Monocyte Clinical Cancer Research cytokines Transplantation 030104 developmental biology pediatric Immunology short-term transplant-related complication short‐term transplant‐related complication Complication business |
| Zdroj: | Cancer Medicine |
| Popis: | Myeloablative conditioning is a well‐established procedure that precedes hematopoietic stem cell transplantation (HSCT), particularly in pediatric patients. In the period directly following transplantation, several factors may contribute to complications that lead to the activation or damage of endothelial cells, involved in the pathogenesis of vascular endothelial syndromes (VES). However, to date, sufficiently specific and sensitive diagnostic markers for the various forms of VES have not been identified. This was a retrospective single‐center study of patients who underwent allogeneic HSCT. For this cohort of patients, parameters including type of engraftment, donor characteristics, and cytokine production were measured and correlated with a high prevalence of short‐term complications after HSCT. The aim of this study was to identify specific parameters useful for improving diagnostics and predicting adverse effects in VES. We confirmed that monocyte‐predominant engraftment was related to a higher risk for an early transplant‐related complication termed sinusoidal obstruction syndrome (SOS). The increased production of specific cytokines, in particular RANTES, represents a marker associated with prevalent engraftment. In addition, patients undergoing prophylaxis with defibrotide had “classical” engraftment, a common cytokine profile and a lower incidence of life‐threatening transplant‐related complications. The beneficial effect of defibrotide might be a starting point for developing selective prophylaxis for patients with monocyte engraftment to prevent severe early transplant‐related complications. The onset of vascular endothelial syndromes after hematopoietic stem cell transplantation is significantly associated with monocyte‐predominant engraftment (P |
| Databáze: | OpenAIRE |
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