SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma Donors

Autor: Morgan Keruly, Imani Burgess, Jernelle Miller, Aaron A.R. Tobian, Patrizio Caturegli, Andrew Pekosz, Eshan U. Patel, William Clarke, Andrew D. Redd, David J. Sullivan, Yolanda Eby, Owen R Baker, Evan M. Bloch, Haley A Schmidt, Ruchee Shrestha, Tania S. Bonny, Thomas C. Quinn, Ethan Klock, Kirsten Littlefield, Arturo Casadevall, Charles S Kirby, Oliver Laeyendecker, Sarah E. Benner, Reinaldo E Fernandez, Shmuel Shoham
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
Convalescent plasma
Adolescent
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Antibody Affinity
Blood Donors
chemical and pharmacologic phenomena
Antibodies
Viral
Cohort Studies
Young Adult
03 medical and health sciences
symbols.namesake
0302 clinical medicine
anti-nucleocapsid
avidity
Major Article
Humans
Immunology and Allergy
Medicine
Avidity
030212 general & internal medicine
Poisson regression
COVID-19 Serotherapy
SARS-CoV-2
anti-spike
business.industry
Immunization
Passive
Antibody titer
COVID-19
Middle Aged
Igg avidity
Antibodies
Neutralizing
Titer
AcademicSubjects/MED00290
Cross-Sectional Studies
030104 developmental biology
Infectious Diseases
Immunoglobulin G
convalescent plasma
Spike Glycoprotein
Coronavirus
Immunology
Linear Models
symbols
Female
business
Zdroj: The Journal of Infectious Diseases
ISSN: 1537-6613
0022-1899
DOI: 10.1093/infdis/jiaa581
Popis: Background Convalescent plasma therapy is a leading treatment for conferring temporary immunity to COVID-19–susceptible individuals or for use as post-exposure prophylaxis. However, not all recovered patients develop adequate antibody titers for donation and the relationship between avidity and neutralizing titers is currently not well understood. Methods SARS-CoV-2 anti-spike and anti-nucleocapsid IgG titers and avidity were measured in a longitudinal cohort of COVID-19 hospitalized patients (n = 16 individuals) and a cross-sectional sample of convalescent plasma donors (n = 130). Epidemiologic correlates of avidity were examined in donors by linear regression. The association of avidity and a high neutralizing titer (NT) were also assessed in donors using modified Poisson regression. Results Antibody avidity increased over duration of infection and remained elevated. In convalescent plasma donors, higher levels of anti-spike avidity were associated with older age, male sex, and hospitalization. Higher NTs had a stronger positive correlation with anti-spike IgG avidity (Spearman ρ = 0.386; P Conclusions SARS-CoV-2 antibody avidity correlated with duration of infection and higher neutralizing titers, suggesting a potential alternative screening parameter for identifying optimal convalescent plasma donors.
Databáze: OpenAIRE
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