Concurrent chemoradiotherapy combined with enteral nutrition support: a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant fistulae
| Autor: | Bo Qiu, Yu Feng Ren, Chun Xia Xie, Yong Hong Hu, Hui Liu, Wen Feng Ye, Qun Li, Guang Yu Luo, Song Ran Liu, L. Ma, Jian Hua Fu, Hong Yang, Shi Liang Liu, Zhao Lin Chen, Meng Zhong Liu |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Neutropenia lcsh:RC254-282 Gastroenterology 03 medical and health sciences Esophageal Fistula 0302 clinical medicine Enteral Nutrition Esophageal squamous cell carcinoma Internal medicine Enteral nutrition support medicine Humans Survival rate Aged Aged 80 and over Univariate analysis Radiotherapy Concurrent chemotherapy business.industry Medical record Cancer Chemoradiotherapy Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Surgery Radiation therapy Parenteral nutrition Oncology 030220 oncology & carcinogenesis Vomiting Carcinoma Squamous Cell 030211 gastroenterology & hepatology Female Original Article medicine.symptom business Malignant fistula |
| Zdroj: | Chinese Journal of Cancer Chinese Journal of Cancer, Vol 36, Iss 1, Pp 1-8 (2017) |
| ISSN: | 1944-446X |
| Popis: | Background Concurrent chemoradiotherapy (CCRT) significantly increases the survival rate of esophageal squamous cell carcinoma (ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long-term survival. Methods We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat-sen University Cancer Center between January 2010 and December 2012. Treatment outcome and toxicity were retrospectively evaluated in 40 ESCC patients with malignant fistulae. All the 40 patients were treated with CCRT and evaluated by clinical nutritionists using nutrition risk screening (NRS) before, during, and after treatment. Twenty-two patients received a nasogastric tube, and 18 underwent percutaneous endoscopic gastrostomy feeding. The median energy intake was 2166 kcal/day. Treatment response was evaluated at 3 months after the completion of CCRT. Results With a median follow-up of 18 months (range, 3–39 months), patients’ 1-year overall survival (OS) rate was 62.5%, and the estimated OS time was 25.5 months. Univariate analysis showed that the NRS score (P = 0.003), increase in NRS score (P = 0.024), fistula closure (P = 0.011), and response to treatment (P |
| Databáze: | OpenAIRE |
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