Effect of hypoalbuminemia and parenteral nutrition on free water excretion and electrolyte-free water resorption
| Autor: | Rex O. Brown, Donald Roberson, Kenneth A. Kudsk, Stacey L. Wojtysiak, Douglas A. Powers |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Oncotic pressure Parenteral Nutrition medicine.medical_specialty Critical Care Nitrogen Serum albumin Natriuresis Urine Critical Care and Intensive Care Medicine Blood Urea Nitrogen Osmotic Pressure Albumins Internal medicine Humans Medicine Colloids Hypoalbuminemia Serum Albumin biology business.industry Metabolic disorder Albumin Middle Aged Water-Electrolyte Balance medicine.disease Surgery Resorption Free water clearance Endocrinology Parenteral nutrition biology.protein Female business |
| Zdroj: | Critical Care Medicine. 20:164-169 |
| ISSN: | 0090-3493 |
| DOI: | 10.1097/00003246-199202000-00005 |
| Popis: | OBJECTIVE To measure the effect of human albumin supplementation during parenteral nutrition on serum albumin concentrations, colloid oncotic pressure, free water clearance, electrolyte-free water resorption, and sodium excretion. DESIGN Prospective, randomized, controlled trial. SETTING Tertiary care center. PATIENTS Thirty adult, hypoalbuminemic patients who required parenteral nutrition. INTERVENTIONS Parenteral nutrition (control) or parenteral nutrition plus human albumin 25 g/L as a continuous infusion (treatment) for a 5-day study period. MEASUREMENTS On days 1 and 5, serum albumin concentration, colloid oncotic pressure, free water clearance, electrolyte-free water resorption, and sodium excretion were measured. RESULTS Serum albumin concentrations increased significantly from day 1 to day 5 in both groups (control: 2.0 +/- 0.1 [mean +/- SEM] vs. 2.3 +/- 0.1 g/dL [20 +/- 1 vs. 23 +/- 1 g/L], p = .02; treatment: 2.2 +/- 0.1 vs. 3.5 +/- 0.2 g/dL [22 +/- 1 vs. 35 +/- 2 g/L], p = .0001). Day 5 serum albumin concentrations were significantly higher in the treatment group compared with control (p = .0001). Colloid oncotic pressure increased significantly from day 1 to day 5 in the treatment group (17.8 +/- 0.8 vs. 25.1 +/- 1.0 mm Hg, p = .0001), and was significantly higher than control at day 5 (p = .0001). No significant differences were found for free water clearance, electrolyte-free water resorption, or sodium excretion within or between groups. CONCLUSIONS In hypoalbuminemic patients, human albumin supplementation during parenteral nutrition results in significant increases in serum albumin concentrations and colloid oncotic pressure, but has no apparent effect on free water clearance, electrolyte-free water resorption, or sodium excretion. |
| Databáze: | OpenAIRE |
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