The Role of the Mouse Y Chromosome on Susceptibility to Testicular Germ Cell Tumors
| Autor: | Colin E. Bishop, Philip D. Anderson, Man-Yee Lam, Christophe Poirier, Joseph H. Nadeau |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
endocrine system Cancer Research Mutant Testicular Germ Cell Tumor Gonadal dysgenesis Biology Y chromosome medicine.disease_cause Article Mice Testicular Neoplasms Y Chromosome medicine Animals Inbreeding Testicular cancer Genetics Chromosome Cancer Neoplasms Germ Cell and Embryonal medicine.disease Mice Inbred C57BL Oncology Female Carcinogenesis |
| Zdroj: | Cancer Research. 69:3614-3618 |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | Testicular germ cell tumors (TGCT) are sex limited, occurring only in males with a Y chromosome. Recently, the gr/gr deletion on the human Y chromosome was associated with increased risk of TGCTs. In addition, the presence of Y chromosome sequences is associated with TGCTs in cases of gonadal dysgenesis. TGCTs in strain 129 males recapitulate many aspects of testicular cancer in human infants and can be used to evaluate the role of the Y chromosome in TGCT risk. We used chromosome substitution strains and a sex-reversing mutant to test the role of the Y chromosome on TGCT susceptibility. Our results show that a Y-linked gene that does not differ among the tested strains is essential for tumorigenesis. [Cancer Res 2009;69(8):3614–8] |
| Databáze: | OpenAIRE |
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