Cell adhesion to acrylic intraocular lens associated with lens surface properties
| Autor: | Takao Tanaka, Naoyuki Yamakawa, Mari Shigeta, Masahiko Usui |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Materials science genetic structures medicine.medical_treatment Phosphorylcholine Acrylic Resins Intraocular lens Cell Count Surface finish law.invention Contact angle Coated Materials Biocompatible law Ophthalmology Surface roughness medicine Cell Adhesion Animals Cell adhesion Cells Cultured Lenses Intraocular Adhesion University hospital eye diseases Sensory Systems Rats Lens (optics) Microscopy Electron Scanning Methacrylates Surgery sense organs Spleen |
| Zdroj: | Journal of cataract and refractive surgery. 31(8) |
| ISSN: | 0886-3350 |
| Popis: | Purpose To examine the number cells adhering to acrylic intraocular lenses (IOLs) having different degrees of surface roughness and acrylic IOLs having different contact angles. Setting Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan. Methods In this study, VA-60CB acrylic IOLs were used. After different durations of polishing of the optics, the roughness values of the lenses were set at 10.0 nm, 2.5 nm, and 0.7 nm. Intraocular lenses were also chemically coated to achieve angles of contact of 100 degrees and 57.5 degrees, with untreated IOLs having a 93.5-degree angle of contact. Intraocular lenses were cultured for 96 hours in 1 × 10 7 spleen cells/mL of developed experimental autoimmune uveoretinitis, and the number of cells adhering to the IOLs was counted. Results Fewer cells adhered to the optics of IOLs with lower roughness values, and fewer cells adhered to the IOL surface with increased contact angles. Conclusion Hydrophobic optics with small roughness values of acrylic IOLs may reduce the number of adherent cells and escaped the unexpected inflammatory cell reaction associated with intraocular inflammation in the eye. |
| Databáze: | OpenAIRE |
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