Decreased Hemoglobin Levels Are Associated with Higher Plasma Level of Fibrinogen, Irrespective of Age
| Autor: | Giorgio Gombos, Salvatore Guastafierro, Marco Sagristani, Adele Nasuti, A. Tirelli, Maria De Biase, Antonino Coppola, Ludovico Coppola, Luigi Ruggiero |
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| Přispěvatelé: | Coppola, L, Guastafierro, Salvatore, Sagristani, M, Coppola, A, Nasuti, A, Ruggiero, L, DE BIASE, M, Tirelli, Armando, Gombos, G. |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Hematocrit Fibrinogen Hemoglobins Sex Factors Internal medicine White blood cell Blood plasma medicine Humans Platelet Aged Aged 80 and over medicine.diagnostic_test business.industry Age Factors General Medicine Middle Aged Fibrinogen Aging Blood rheology Hemoglobin Platelet Blood Cell Count Red blood cell Endocrinology medicine.anatomical_structure Immunology Regression Analysis Female Hemorheology Hemoglobin business Blood Chemical Analysis medicine.drug |
| Zdroj: | The American Journal of the Medical Sciences. 333:154-160 |
| ISSN: | 0002-9629 |
| DOI: | 10.1097/maj.0b013e3180312547 |
| Popis: | Background: Increased plasma levels of fibrinogen are been associated with an increased risk of cardiovascular accident. We aimed at verifying whether the changes of fibrinogen levels are associated with red blood cell (and/or hemoglobin) concentration. Methods: A group of 381 carefully selected healthy volunteers (219 male and 162 female), aged from 18 to 101 years, were enrolled in this study. Fasting blood samples were taken and all measurements (fibrinogen plasma level, whole blood viscosity, hemoglobin concentration, hematocrit value, red blood cell and white blood cell count, platelet count, glucose, total cholesterol and triglycerides plasma concentration, and C-reactive protein level) were obtained with standardized methodology using appropriate equipment, procedures, and controls. Results and Conclusions: In the male but not in the female group, plasma fibrinogen concentration inversely correlated with hemoglobin (P * 0.0001) and hematocrit value (P * 0.01). In a post hoc analysis, plasma fibrinogen level inversely correlated with hemoglobin in the subgroup of the 93 premenopausal women and directly correlated with age and inversely correlated with platelet count in the subgroup of the 69 postmenopausal women. Results of multiple regression analysis revealed that in all the subjects, except in the postmenopausal women, hemoglobin level is an independent predictor of fibrinogen plasma level. Considering the physiopathologic role of increased plasma fibrinogen concentration and the scarcity of pharmacologic approaches to decrease its level, these findings could be important in designing a preventive therapy of cardiovascular disease |
| Databáze: | OpenAIRE |
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