The H/Rouen mouse model displays depression-like and anxiety-like behaviors
| Autor: | J.-M. Vaugeois, Malika El Yacoubi, Virginie Rappeneau, Eddy Champion, Gaël Malleret |
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| Přispěvatelé: | Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Sucrose Anhedonia Mouse Drinking Behavior Learned helplessness Mice Inbred Strains Comorbidity Motor Activity Neuropsychological Tests Anxiety 03 medical and health sciences Behavioral Neuroscience Food Preferences 0302 clinical medicine Animal model Species Specificity Internal medicine Fluoxetine medicine Animals Psychiatry Depression (differential diagnoses) 030304 developmental biology 0303 health sciences Depressive disorder Tail suspension test Disease Models Animal Endocrinology Anxiogenic Exploratory Behavior Antidepressive Agents Second-Generation Female medicine.symptom Psychology 030217 neurology & neurosurgery [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology medicine.drug |
| Zdroj: | Behavioural Brain Research Behavioural Brain Research, Elsevier, 2013, 256, pp.43-50. ⟨10.1016/j.bbr.2013.07.048⟩ |
| ISSN: | 0166-4328 1872-7549 |
| DOI: | 10.1016/j.bbr.2013.07.048⟩ |
| Popis: | Cardinal symptoms of depression include helplessness and anhedonia. In addition, depression and anxiety are often comorbid disorders. H/Rouen mice, a genetic mouse model of depression, display helpless behavior in the tail suspension test, whereas non-helpless NH/Rouen mice show the opposite behavior. It is unknown whether H/Rouen mice display an anxious behavior as compared to NH/Rouen mice, and is unclear whether they display anhedonia. Time spent in the periphery of an open-field, an index of anxiety, was found to be higher in male and female H/Rouen mice as compared to NH/Rouen mice. In the elevated plus-maze, a decrease in the number of entries and in the time spent in the open arms was observed in both male and female H/Rouen. In the light/dark box, the number of entries and the time spent in the anxiogenic bright compartment was significantly reduced in male and female H/Rouen mice. In addition, the preference of consumption of a 2% sucrose solution was significantly reduced in male and female H/Rouen mice as compared to NH/Rouen and I/Rouen mice in a two-bottle choice paradigm but was restored by a chronic (3 weeks) fluoxetine treatment. H/Rouen mice thus display both anxiety and anhedonia making them a potent animal model in the treatment of forms depression comorbidly expressed with anxiety. |
| Databáze: | OpenAIRE |
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