Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot
| Autor: | Meng Cui, Min-Hui Li, Zhidi Wang, Lingyan Zhao, Yanping Zhao, Le Chen, Yumin Gao, Hui Pang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Article Subject 030209 endocrinology & metabolism Type 2 diabetes ADIPOQ Gene Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans Genetic Predisposition to Disease Aged Genetics General Immunology and Microbiology Multifactor dimensionality reduction Adiponectin business.industry Haplotype Type 2 Diabetes Mellitus nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Obesity 030104 developmental biology Diabetes Mellitus Type 2 Medicine Female Gene polymorphism business Research Article |
| Zdroj: | BioMed Research International, Vol 2020 (2020) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Objective. The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at providing approaches for the prevention and control of T2DM in combination with the characteristics of the local population. Methods. A case-control study was conducted including 406 Chinese participants, comprising 203 cases and 203 controls from various hospitals. Adiponectin (ADIPOQ) gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were detected using an improved multiple ligation detection reaction technique. Generalized multifactor dimensionality reduction (GMDR) and logistic regression were conducted to analyze the associations between adiponectin gene polymorphisms and T2DM, as well as the interactions between adiponectin gene polymorphisms and environmental factors. Results. ADIPOQ gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were associated with type 2 diabetes. Based on the haplotype of the five adiponectin gene single-nucleotide polymorphism (SNP) loci, we found that G-G-A-A-C was a susceptible haplotype of T2DM (P<0.05). Interaction analyses demonstrated associations between rs1501299 and central obesity (consistency=80%, P=0.011) and between rs266729 and rs182052 and central obesity (consistency=70%, P=0.011). Conclusions. Our findings indicate that there is an interaction between the ADIPOQ gene and central obesity, which provides new insights into the prevention and treatment of T2DM. |
| Databáze: | OpenAIRE |
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