Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy

Autor: Mariola Sulkowska, Eva Surmacz, Stanislaw Sulkowski, Luiza Kanczuga-Koda, Mariusz Koda
Jazyk: angličtina
Předmět:
Oncology
Adult
Leptin
medicine.medical_specialty
Cancer Research
Estrogen receptor
Breast Neoplasms
lcsh:RC254-282
Breast cancer
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Biomarkers
Tumor
Genetics
Humans
Estrogen receptor beta
Aged
Neoplasm Staging
Aged
80 and over
Glucose Transporter Type 1
Leptin receptor
Tumor hypoxia
business.industry
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Hypoxia-Inducible Factor 1
alpha Subunit
Metastatic breast cancer
Immunohistochemistry
Cell Hypoxia
Neoadjuvant Therapy
Ki-67 Antigen
Treatment Outcome
Receptors
Estrogen
Chemotherapy
Adjuvant
Lymphatic Metastasis
Receptors
Leptin
Female
business
Estrogen receptor alpha
hormones
hormone substitutes
and hormone antagonists
Research Article
Zdroj: BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 320 (2010)
ISSN: 1471-2407
DOI: 10.1186/1471-2407-10-320
Popis: Background Tumor hypoxia is marked by enhanced expression of hypoxia-inducible factor-α (HIF-1α) and glucose transporter-1 (Glut-1). Hypoxic conditions have also been associated with overexpression of angiogenic factors, such as leptin. The aim of our study was to analyze the relationships between hypoxia markers HIF-1α, Glut-1, leptin, leptin receptor (ObR) and other breast cancer biomarkers in primary and metastatic breast cancer in patients treated or untreated with preoperative chemotherapy. Methods The expression of different biomarkers was examined by immunohistochemistry in 116 primary breast cancers and 65 lymph node metastases. Forty five of these samples were obtained form patients who received preoperative chemotherapy and 71 from untreated patients. Results In primary tumors without preoperative chemotherapy, HIF-1α and Glut-1 were positively correlated (p = 0.02, r = 0.437). HIF-1α in primary and metastatic tumors without preoperative therapy positively correlated with leptin (p < 0.0001, r = 0.532; p = 0.013, r = 0.533, respectively) and ObR (p = 0.002, r = 0.319; p = 0.083, r = 0.387, respectively). Hypoxia markers HIF-1α and Glut-1 were negatively associated with estrogen receptor alpha (ERα) and positively correlated with estrogen receptor beta (ERβ). In this group of tumors, a positive correlation between Glut-1 and proliferation marker Ki-67 (p = 0.017, r = 0.433) was noted. The associations between HIF-1α and Glut-1, HIF-1α and leptin, HIF-1α and ERα as well as Glut-1 and ERβ were lost following preoperative chemotherapy. Conclusions Intratumoral hypoxia in breast cancer is marked by coordinated expression of such markers as HIF-1α, Glut-1, leptin and ObR. The relationships among these proteins can be altered by preoperative chemotherapy.
Databáze: OpenAIRE
Externí odkaz: