Gastric Antigen Challenge Releases Gastrin and Eicosanoids and Protects against Ethanol
| Autor: | Brigitta M. Peskar, Georg Enders, Emile A. Bacha, Emilio Dominguez Fernandez, H.-J. Krämling, Thomas Stroff |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Synthetic antigen Indomethacin Stomach Diseases Prostaglandin 6-Ketoprostaglandin F1 alpha Biology Dinoprost chemistry.chemical_compound Antigen Internal medicine Gastrins medicine Gastric mucosa Animals Antigens Rats Wistar Gastrin Leukotriene Ethanol Stomach digestive oral and skin physiology Nitrohydroxyiodophenylacetate Leukotriene C4 Rats medicine.anatomical_structure Endocrinology Eicosanoid chemistry Gastric Mucosa Eicosanoids Surgery |
| Zdroj: | Journal of Surgical Research. 70:69-74 |
| ISSN: | 0022-4804 |
| Popis: | Various gastrointestinal functions such as mucosal blood flow and mucus secretion can be influenced immunologically. Rats were systemically sensitized with 4-hydroxy-3-iodo-5-nitro-phenylacetic acid (NIP), a synthetic antigen. Mucosal release of gastrin, prostaglandin F2 alpha, 6-keto-prostaglandin F1 alpha, and leukotriene C4 was measured after intragastric or in vitro antigen challenge. Gastric protection from ethanol was determined. In sensitized rats, intragastric antigen challenge increased release of gastrin from the antral mucosa ex vivo and tended to increase release of prostaglandin F2 alpha. Likewise, antral mucosa of sensitized rats released significantly more gastrin and prostaglandin F2 alpha during in vitro antigen challenge than during incubation in the absence of antigen. Release of 6-keto-prostaglandin F1 alpha and leukotriene C4 was not affected by the immunologic reaction. Topical antigen challenge in sensitized rats reduced gastric mucosal damage caused by ethanol by 50%. The immunologically induced gastroprotection was significantly attenuated by pretreatment with indomethacin. The findings show that specific antigen challenge renders the gastric mucosa more resistant against the injurious effect of ethanol indicating that the stomach is a target organ of immunological reactions. As gastrin and prostaglandins exert potent protective effects, release of these mediators may contribute to the protective response to gastric mucosal immune activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect