Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress: A Combined Clinical and Finite Element Study

Autor: Peter R. Hoskins, Olivia M.B. McBride, Chengjia Wang, David E. Newby, Calum Gray, Scott Ian Kay Semple, Rachael O. Forsythe, L. Hollis, Jennifer M. J. Robson, Barry J. Doyle, Edwin J R van Beek, Noel Conlisk, Tom MacGillivray
Rok vydání: 2017
Předmět:
Male
Patient-Specific Modeling
Computed Tomography Angiography
Contrast Media
Pharmaceutical Science
02 engineering and technology
030204 cardiovascular system & hematology
0302 clinical medicine
Rupture risk
Aorta
Abdominal
Prospective Studies
Magnetite Nanoparticles
Genetics (clinical)
Aged
80 and over
medicine.diagnostic_test
Models
Cardiovascular
Dextrans
Magnetic Resonance Imaging
Abdominal aortic aneurysm
Disease Progression
cardiovascular system
Molecular Medicine
Female
Original Article
Radiology
Cardiology and Cardiovascular Medicine
Dilatation
Pathologic
MRI
medicine.medical_specialty
USPIO uptake
Patient-specific modelling
Aortic Rupture
Finite Element Analysis
0206 medical engineering
Aortography
Risk Assessment
Finite element study
Stress (mechanics)
03 medical and health sciences
Aneurysm
Predictive Value of Tests
Journal Article
Genetics
medicine
Humans
cardiovascular diseases
Aged
Aortitis
business.industry
Disease progression
Magnetic resonance imaging
medicine.disease
020601 biomedical engineering
Scotland
Regional Blood Flow
Stress
Mechanical
Fe model
Abdominal aortic aneurysms
business
Aortic Aneurysm
Abdominal
Zdroj: Journal of Cardiovascular Translational Research
Conlisk, N, Forsythe, R, Hollis, L, Doyle, B J, McBride, O, Robson, J, Wang, C, Gray, C D, Semple, S I K, MacGillivray, T, van Beek, E J R, Newby, D E & Hoskins, P R 2017, ' Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress : A Combined Clinical and Finite Element Study ', Journal of cardiovascular translational research . https://doi.org/10.1007/s12265-017-9766-9
ISSN: 1937-5395
1937-5387
Popis: Inflammation detected through the uptake of ultrasmall superparamagnetic particles of iron oxide (USPIO) on magnetic resonance imaging (MRI) and finite element (FE) modelling of tissue stress both hold potential in the assessment of abdominal aortic aneurysm (AAA) rupture risk. This study aimed to examine the spatial relationship between these two biomarkers. Patients (n = 50) > 40 years with AAA maximum diameters > = 40 mm underwent USPIO-enhanced MRI and computed tomography angiogram (CTA). USPIO uptake was compared with wall stress predictions from CTA-based patient-specific FE models of each aneurysm. Elevated stress was commonly observed in areas vulnerable to rupture (e.g. posterior wall and shoulder). Only 16% of aneurysms exhibited co-localisation of elevated stress and mural USPIO enhancement. Globally, no correlation was observed between stress and other measures of USPIO uptake (i.e. mean or peak). It is suggested that cellular inflammation and stress may represent different but complimentary aspects of AAA disease progression. Electronic supplementary material The online version of this article (doi:10.1007/s12265-017-9766-9) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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