JmjC-domain-containing proteins and histone demethylation
| Autor: | Yi Zhang, Robert J. Klose, Eric M. Kallin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Epigenetic regulation of neurogenesis
Transcription Genetic Histone lysine methylation Amino Acid Motifs Molecular Sequence Data Biology Epigenesis Genetic Histones Histone demethylation Histone methylation Genetics Histone code Animals Humans Amino Acid Sequence Protein Methyltransferases Histone demethylase activity Molecular Biology Genetics (clinical) Phylogeny Epigenomics Nuclear Proteins Oxidoreductases N-Demethylating Histone-Lysine N-Methyltransferase Protein Structure Tertiary Biochemistry Gene Expression Regulation Histone methyltransferase Histone Methyltransferases Sequence Alignment |
| Popis: | Histone methylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove methyl marks from histones have recently been identified, revealing a new level of plasticity within this epigenetic modification system. Here we analyse the evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins and discuss their cellular functions in relation to their potential enzymatic activities. |
| Databáze: | OpenAIRE |
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