Determination of pentoxifylline in serum by high-performance thin-layer chromatography
| Autor: | Z. Kállay, Katarína Bauerová, Katarína Schmidtová, L. Šoltés |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Clinical Biochemistry
Administration Oral Biological Availability Pharmaceutical Science Biological fluid Dosage form Analytical Chemistry Pentoxifylline Dogs Pharmacokinetics Drug Discovery medicine Animals High performance thin layer chromatography Spectroscopy Chromatography Chemistry Extraction (chemistry) Thin-layer chromatography Bioavailability Delayed-Action Preparations Injections Intravenous Chromatography Thin Layer Half-Life medicine.drug |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 9:247-250 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/0731-7085(91)80153-z |
| Popis: | An analytical method to study the bioavailability of newly developed pentoxifylline sustained-release tablets has been developed and assessed in experiments on dogs. For the isolation of pentoxifylline and its metabolites from serum solid—liquid extraction was applied by involving the internal standard probe. HPTLC plates with a preconcentration zone were used for separation of the analysed substances, using chloroform—methanol (95:5, v/v). Quantification was by densitometric detection. The detector response was linear in the concentration range investigated for pentoxifylline: 0.02–1.5 μg ml −1 of serum. |
| Databáze: | OpenAIRE |
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