Reversing intravenous sedation with flumazenil
| Autor: | Stephen A. Cooper, Debbie McKenna, Peter D. Quinn, Kenneth MacAfee |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Flumazenil Male medicine.medical_specialty Time Factors Adolescent Consciousness Meperidine Midazolam Sedation medicine.medical_treatment Conscious Sedation Intravenous sedation Oral Surgical Procedures Pathology and Forensic Medicine Placebos Cognition medicine Humans General Dentistry Aged Psychomotor learning Chemotherapy business.industry Awareness Middle Aged Surgery Anesthesia Mental Recall Anesthesia Intravenous Female medicine.symptom business Psychomotor Performance medicine.drug |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology. 72:2-9 |
| ISSN: | 0030-4220 |
| Popis: | This study was designed to evaluate the effects of flumazenil in reversing sedation from midazolam and meperidine after oral surgical procedures. Of the 35 patients entered, efficacy was evaluated in 33 and safety in 34. Patients were tested for sedation, psychomotor skills, and memory during a 3-hour period and at a 24-hour follow-up. Flumazenil almost totally reversed the effects of sedation for approximately 2 hours, after which some loss of effect was observed. A number of central nervous system-related side effects were observed in the flumazenil group, but none of these was considered serious. One patient in the flumazenil group had an episode of hypotension that precluded further testing. |
| Databáze: | OpenAIRE |
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