Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation
Autor: | Puo-Hsien Le, Tsung-Hsing Chen, Chia-Jung Kuo, Chih-Lang Lin, Kung-Hao Liang, Yi-Chung Hsieh, Chau-Ting Yeh |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Carcinoma Hepatocellular Polymorphism Single Nucleotide Gastroenterology lcsh:RC254-282 Young Adult Life Expectancy Surgical oncology Internal medicine Ascites Odds Ratio Genetics medicine Humans Genetic Predisposition to Disease Age of Onset Glucuronosyltransferase Neoplasm Metastasis Genetic Association Studies Viral etiology Aged Aged 80 and over Variant type business.industry Liver Neoplasms Odds ratio Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Analysis Confidence interval Alcoholism Oncology Young hepatocellular carcinoma age of death Hepatocellular carcinoma Life expectancy Xenobiotic metabolizing enzymes Female Neoplasm Recurrence Local medicine.symptom business Research Article |
Zdroj: | BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019) BMC Cancer |
ISSN: | 1471-2407 |
Popis: | Background Hepatocellular carcinoma (HCC) is an aggressive solid tumor. HCC occurred at younger and elder ages were considered driven by different oncogenic mechanisms, and they demonstrated distinct clinical courses. Methods A total of 382 HCC patients treated by surgical resections was analyzed. Results A univariate-multivariate analysis showed that viral etiology (chronic hepatitis B, C) and the UDP glucuronosyltransferase family 2 member B28 (UGT2B28) genomic variant rs2132039 were independently associated with the age at presentation of HCC (all adjusted P P = 0.037) and ascites (OR, 3.505; CI, 1.358–9.048; adjusted P = 0.010) were two independent factors associated with this genomic variant. The age was 54.1 ± 14.6 years for patients with the “TT” variant type, and 58.2 ± 13.7 years for those with the “Non-TT” variant type. The age disparity was most prominent in alcoholic patients (OR, 1.079; CI, 1.035–1.125; P P = 0.025), distant metastasis (P = 0.024) and HCC-related death (P = 0.008) in non-censored patients. Conclusions An UGT2B28 genomic variant was indicative of the age of HCC presentation, recurrence, distant metastasis and death. |
Databáze: | OpenAIRE |
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