Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation

Autor: Puo-Hsien Le, Tsung-Hsing Chen, Chia-Jung Kuo, Chih-Lang Lin, Kung-Hao Liang, Yi-Chung Hsieh, Chau-Ting Yeh
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
Cancer Research
medicine.medical_specialty
Carcinoma
Hepatocellular
Polymorphism
Single Nucleotide
Gastroenterology
lcsh:RC254-282
Young Adult
Life Expectancy
Surgical oncology
Internal medicine
Ascites
Odds Ratio
Genetics
medicine
Humans
Genetic Predisposition to Disease
Age of Onset
Glucuronosyltransferase
Neoplasm Metastasis
Genetic Association Studies
Viral etiology
Aged
Aged
80 and over
Variant type
business.industry
Liver Neoplasms
Odds ratio
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Survival Analysis
Confidence interval
Alcoholism
Oncology
Young hepatocellular carcinoma
age of death
Hepatocellular carcinoma
Life expectancy
Xenobiotic metabolizing enzymes
Female
Neoplasm Recurrence
Local
medicine.symptom
business
Research Article
Zdroj: BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Cancer
ISSN: 1471-2407
Popis: Background Hepatocellular carcinoma (HCC) is an aggressive solid tumor. HCC occurred at younger and elder ages were considered driven by different oncogenic mechanisms, and they demonstrated distinct clinical courses. Methods A total of 382 HCC patients treated by surgical resections was analyzed. Results A univariate-multivariate analysis showed that viral etiology (chronic hepatitis B, C) and the UDP glucuronosyltransferase family 2 member B28 (UGT2B28) genomic variant rs2132039 were independently associated with the age at presentation of HCC (all adjusted P P = 0.037) and ascites (OR, 3.505; CI, 1.358–9.048; adjusted P = 0.010) were two independent factors associated with this genomic variant. The age was 54.1 ± 14.6 years for patients with the “TT” variant type, and 58.2 ± 13.7 years for those with the “Non-TT” variant type. The age disparity was most prominent in alcoholic patients (OR, 1.079; CI, 1.035–1.125; P P = 0.025), distant metastasis (P = 0.024) and HCC-related death (P = 0.008) in non-censored patients. Conclusions An UGT2B28 genomic variant was indicative of the age of HCC presentation, recurrence, distant metastasis and death.
Databáze: OpenAIRE
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