Peroxisomal enzymes in the liver of rats with experimental diabetes mellitus type 2
| Autor: | E Uhlikova, Turecký L, Mojto, Kupcová |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.disease_cause Diabetes Mellitus Experimental Internal medicine Diabetes mellitus medicine Peroxisomes Animals Rats Wistar Beta oxidation chemistry.chemical_classification Reactive oxygen species biology Chemistry Fatty liver General Medicine Peroxisome medicine.disease Endocrinology Enzyme Animals Newborn Diabetes Mellitus Type 2 Liver Catalase biology.protein sense organs Oxidative stress |
| Zdroj: | Physiological research. 63(Suppl 4) |
| ISSN: | 1802-9973 |
| Popis: | Diabetes mellitus is relatively frequently associated with fatty liver disease. Increased oxidative stress probably plays an important role in the development of this hepatopathy. One of possible sources of reactive oxygen species in liver is peroxisomal system. There are several reports about changes of peroxisomal enzymes in experimental diabetes, mainly enzymes of fatty acid oxidation. The aim of our study was to investigate the possible changes of activities of liver peroxisomal enzymes, other than enzymes of beta-oxidation, in experimental diabetes mellitus type 2. Biochemical changes in liver of experimental animals suggest the presence of liver steatosis. The changes of serum parameters in experimental group are similar to changes in serum of patients with non-alcoholic fatty liver disease. We have shown that diabetes mellitus influenced peroxisomal enzymes by the different way. Despite of well-known induction of peroxisomal beta-oxidation, the activities of catalase, aminoacid oxidase and NADH-cytochrome b5 reductase were not significantly changed and the activities of glycolate oxidase and NADP-isocitrate dehydrogenase were significantly decreased. The effect of diabetes on liver peroxisomes is probably due to the increased supply of fatty acids to liver in diabetic state and also due to increased oxidative stress. The changes of metabolic activity of peroxisomal compartment may participate on the development of diabetic hepatopathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|