Enhancing the water-solubility of curcuminoids-rich extract using a ternary inclusion complex system: Preparation, characterization, and anti-cancer activity
| Autor: | Nattha Kaewnopparat, Likit Lateh, Pharkphoom Panichayupakaranant, Supreeya Yuenyongsawad |
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| Rok vydání: | 2021 |
| Předmět: |
Aqueous solution
Polyvinylpyrrolidone biology Calorimetry Differential Scanning Chemistry Plant Extracts Extraction (chemistry) Water General Medicine biology.organism_classification Analytical Chemistry HeLa Differential scanning calorimetry Solubility X-Ray Diffraction Diarylheptanoids Spectroscopy Fourier Transform Infrared medicine Humans Ternary operation Ternary complex Food Science medicine.drug Nuclear chemistry |
| Zdroj: | Food chemistry. 368 |
| ISSN: | 1873-7072 |
| Popis: | Curcuminoids are known to exert diverse pharmacological effects and used in some pharmaceutical formulations. This study describes the preparation, characterization, and enhancement in the solubility and anticancer activity of a curcuminoids-rich extract (CRE) using a ternary inclusion complex system. CRE containing 88.9% w/w curcuminoids was prepared using a ‘green’ microwave extraction coupled with fractionation on a column of hydrophobic adsorbent resin. The ternary complex consisting of CRE, hydroxylpropyl-β-cyclodextrin and polyvinylpyrrolidone K30 was prepared using the solvent evaporation method and thoroughly characterized using Fourier-transform infrared spectroscopy, powder X-ray diffractograms, differential scanning calorimetry and scanning electron microscopy. The ternary complex of CRE improved the water-solubility of curcuminoids (up to 70.3 µg/mL) as well as the dissolution rate when compared to those of CRE (0 µg/mL). In addition, the ternary complex exhibited significantly stronger anticancer activity against human lung adenocarcinoma (A-549), human cervical adenocarcinoma (HeLa) and human colon adenocarcinoma (HT-29) cell lines than CRE. |
| Databáze: | OpenAIRE |
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