Synthesis of new pyrrolo[1,2-d][1,2,4]triazines and thiazolo[3,4-d][1,2,4]triazines as immunostimulating agents
| Autor: | Pascal Coudert, Véronique Spehner, Veronique Issartel, Jacques Couquelet, Estelle Seilles |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.drug_class
Stereochemistry Radical Clinical Biochemistry Tetrazolium Salts Pharmaceutical Science Stimulation Lymphocyte Activation Biochemistry Immunostimulant D-1 Structure-Activity Relationship chemistry.chemical_compound Adjuvants Immunologic Drug Discovery medicine Humans Structure–activity relationship Lymphocytes Molecular Biology Triazine Triazines Hydantoins Organic Chemistry Zymosan Stimulation Chemical Proliferative response Thiazoles Pyrimidines chemistry Luminescent Measurements Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry. 6:349-354 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/s0968-0896(97)10052-9 |
| Popis: | Four pyrrolo[1,2-d][1,2,4]triazines and four thiazolo[3,4-d][1,2,4]triazines were synthesized from trans-4-hydroxy-L-proline and L-thiaproline, respectively. The synthetic route involved formation of hydrazides followed by cyclization with orthoesters. The proliferative response to human lymphocyte mitogen (phytohemagglutinin) revealed significant immunostimulant activity for all test drugs. Furthermore, some triazine derivatives were effective to activate production of free oxygen radical by phagocytes in response to stimulation by opsonized zymosan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect