The pruritogenic role of the type 2 immune response in diseases associated with chronic itch
| Autor: | Giampiero Girolomoni, Giuseppe Ingrasci, Zoe M. Lipman, Ahmed A. Hawash, Gil Yosipovitch |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Keratinocytes
0301 basic medicine T cells Inflammation Dermatology Biochemistry Dermatitis Atopic Type 2 immune response Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences Th2 Cells 0302 clinical medicine Immune system Humans Medicine itch Chronic itch Molecular Biology business.industry Pruritus biomarkers Atopic dermatitis medicine.disease 030104 developmental biology inflammation Immunology Cytokines medicine.symptom business Chronic pruritus |
| Zdroj: | Experimental Dermatology. 30:1208-1217 |
| ISSN: | 1600-0625 0906-6705 |
| DOI: | 10.1111/exd.14401 |
| Popis: | While there is a vast array of aetiologies that may lead to chronic pruritus, recent data suggests that many of these conditions share similar interactions between keratinocytes, nerves, and the immune system. Specifically, the type 2 immune response, including Th2 T Cells and their related cytokines, has been noted to play a major role in the development of pruritus in a variety of itchy conditions. To date, atopic dermatitis is the most striking example of this pathogenesis. However, the body of literature supporting its role in many other itchy conditions, including other inflammatory, bullous, as well as systemic diseases, continues to grow. In addition, new treatments targeting this type 2 immune system continue to be developed and investigated. In the current review, we present the current body of literature supporting the role of the type 2 immune response in itchy conditions beyond atopic dermatitis as well as potential therapeutic options that target this pathway for chronic itch. |
| Databáze: | OpenAIRE |
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