Sex-Specific Effect of High-Fat Diet on Glycerol Metabolism in Murine Adipose Tissue and Liver

Autor: Janne Lebeck, Francesco Maria Iena, Jesper Skovhus Thomsen, Johanne Blanner Jul, Annemarie Brüel, Jens Bay Vegger, Andreas Lodberg
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
sex differences
Glycerol
Male
medicine.medical_specialty
Glycerol kinase
Metabolic Clearance Rate
Endocrinology
Diabetes and Metabolism
Adipose tissue
030209 endocrinology & metabolism
Biology
liver
Aquaporins
Diet
High-Fat
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Endocrinology
Sex Factors
Adipocyte
Internal medicine
medicine
Adipocytes
Animals
aquaglyceroporins
Triglycerides
Original Research
lcsh:RC648-665
Liraglutide
digestive
oral
and skin physiology
food and beverages
nutritional and metabolic diseases
Metabolism
medicine.disease
adipose tissue
Fatty Liver
Mice
Inbred C57BL
030104 developmental biology
chemistry
Female
Steatosis
medicine.symptom
Weight gain
medicine.drug
Zdroj: Frontiers in Endocrinology
Iena, F M, Jul, J B, Vegger, J B, Lodberg, A, Thomsen, J S, Brüel, A & Lebeck, J 2020, ' Sex-Specific Effect of High-Fat Diet on Glycerol Metabolism in Murine Adipose Tissue and Liver ', Frontiers in Endocrinology, vol. 11, 577650 . https://doi.org/10.3389/fendo.2020.577650
Frontiers in Endocrinology, Vol 11 (2020)
ISSN: 1664-2392
Popis: Obesity is associated with increased plasma glycerol levels. The coordinated regulation of glycerol channels in adipose tissue (AQP7) and the liver (AQP9) has been suggested as an important contributor to the pathophysiology of type-2-diabetes mellitus, as it would provide glycerol for hepatic synthesis of glucose and triglycerides. The regulation of AQP7 and AQP9 is influenced by sex. This study investigates the effect of a high-fat diet (HFD) on glycerol metabolism in mice and the influence of sex and GLP-1-receptor agonist treatment. Female and male C57BL/6JRj mice were fed either a control diet or a HFD for 12 or 24 weeks. Liraglutide was administered (1 mg/kg/day) to a subset of female mice. After 12 weeks of HFD, females had gained less weight than males. In adipose tissue, only females demonstrated an increased abundance of AQP7, whereas only males demonstrated a significant increase in glycerol kinase abundance and adipocyte size. 24 weeks of HFD resulted in a more comparable effect on weight gain and adipose tissue in females and males. HFD resulted in marked hepatic steatosis in males only and had no significant effect on the hepatic abundance of AQP9. Liraglutide treatment generally attenuated the effects of HFD on glycerol metabolism. In conclusion, no coordinated upregulation of glycerol channels in adipose tissue and liver was observed in response to HFD. The effect of HFD on glycerol metabolism is sex-specific in mice, and we propose that the increased AQP7 abundance in female adipose tissue could contribute to their less severe response to HFD.
Databáze: OpenAIRE
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