Using Adoptive Cellular Therapy for Localized Protein Secretion
| Autor: | Heather K. Lin, Sarwish Rafiq, Alysa N. Evans, A K M Nawshad Hossian |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Tumor microenvironment Receptors Chimeric Antigen T-Lymphocytes Receptors Antigen T-Cell Biology Immunotherapy Adoptive Chimeric antigen receptor Article 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Secretory protein Oncology 030220 oncology & carcinogenesis Neoplasms Cancer research Tumor Microenvironment Adoptive cellular therapy Distribution (pharmacology) Humans In patient Secretion Function (biology) |
| Zdroj: | Cancer J |
| ISSN: | 1540-336X |
| Popis: | Redirection of T cell cytotoxicity by the chimeric antigen receptor (CAR) structure may not be sufficient for optimal antitumor function in the patient tumor microenvironment. Comodifying CAR T cells to secrete different classes of proteins can be used to optimize CAR T cell function, overcome suppressive signals, and/or alter the tumor microenvironment milieu. These modifications aim to improve initial responses to therapy and enhance the durability of response. Furthermore, CAR T cells can deliver these molecules locally to the tumor microenvironment, avoiding systemic distribution. This approach has been tested in preclinical models using a variety of different classes of agonistic and antagonistic proteins, and clinical trials are currently underway to assess efficacy in patients. |
| Databáze: | OpenAIRE |
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