Phase II clinical study of boron neutron capture therapy combined with X-ray radiotherapy/temozolomide in patients with newly diagnosed glioblastoma multiforme--study design and current status report
| Autor: | Toshihiko Kuroiwa, Shinji Kawabata, Koji Ono, Yuki Hirota, Yoko Takekita, Shin-Ichi Miyatake, Shiro Miyata, Mitsunori Kirihata, Ryo Hiramatsu, Yoshinori Sakurai, Akira Maruhashi |
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| Rok vydání: | 2010 |
| Předmět: |
Radiation
Temozolomide Combination therapy business.industry Brain Neoplasms medicine.medical_treatment Dacarbazine Antineoplastic Agents Boron Neutron Capture Therapy medicine.disease Combined Modality Therapy Clinical study Radiation therapy Neutron capture medicine Humans Nuclear medicine business Glioblastoma medicine.drug |
| Zdroj: | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 69(12) |
| ISSN: | 1872-9800 |
| Popis: | Recently, we reported our clinical experiences of boron neutron capture therapy (BNCT) for the newly diagnosed glioblastoma. The major differences of our protocol from the other past studies were simultaneous use of both sodium borocapate and boronophenylalanine, and combination with fractionated X-ray irradiation. These results showed the efficacy of combination therapy with external beam X-ray irradiation and BNCT. For our future study, we planned the multi-centric phase II clinical study for newly diagnosed glioblastoma patients in Japan (OSAKA-TRIBRAIN0902, NCT00974987). |
| Databáze: | OpenAIRE |
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