Cardioprotective effects of T3-146, a cyclic derivative of γ-aminobutyric acid, under conditions of reperfusion
| Autor: | A. I. Khankoeva, P. A. Galenko-Yaroshevskii, S. A. Kryzhanovskii, P. B. Popov, A. V. Uvarov, A. Yu. Turovaya |
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| Předmět: |
Cardiac function curve
medicine.medical_specialty Ischemia Piracetam Hemodynamics General Medicine Pharmacology medicine.disease Aminobutyric acid General Biochemistry Genetics and Molecular Biology Lipid peroxidation chemistry.chemical_compound Left coronary artery chemistry medicine.artery Internal medicine medicine Cardiology Structural analog medicine.drug |
| Zdroj: | Scopus-Elsevier |
| Popis: | Intravenous injection of T3-146, a cyclic derivative of γ-aminobutyric acid (structural analog of piracetam), 5 min prior to reperfusion of the descendent branch of the left coronary artery prevents the development of serious rhythm disturbances and stabilizes hemodynamics and cardiac function. These effects are probably due to the inhibitory effect of this compound on lipid peroxidation in the myocardium. |
| Databáze: | OpenAIRE |
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