Oxidative stress markers are associated to vascular recurrence in non-cardioembolic stroke patients non-treated with statins
| Autor: | Tomás Segura, Jorge Garcia-García, Jose Castillo, Jose Manuel Molto Jorda, Gemma Serrano-Heras, Exuperio Diez Tejedor, David Brea Lopez, José María Ramirez-Moreno, Sergio Calleja, Jaume Roquer Gonzalez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Neurology Heart Diseases Embolism Clinical Neurology Atherothrombosis Comorbidity medicine.disease_cause Gastroenterology lcsh:RC346-429 Recurrence Risk Factors Internal medicine medicine Prevalence Humans Neurochemistry Stroke lcsh:Neurology. Diseases of the nervous system Aged chemistry.chemical_classification Aged 80 and over Reactive oxygen species Ischemic stroke business.industry General Medicine Middle Aged medicine.disease Surgery Vascular recurrence Cerebrovascular Disorders Oxidative Stress chemistry Intima-media thickness Spain Female Neurology (clinical) Hydroxymethylglutaryl-CoA Reductase Inhibitors business Reactive Oxygen Species Oxidative stress Biomarkers Research Article |
| Zdroj: | BMC Neurology BMC Neurology, Vol 12, Iss 1, p 65 (2012) RUNA. Repositorio da Consellería de Sanidade e Sergas Servizo Galego de Saúde (SERGAS) |
| ISSN: | 1471-2377 |
| Popis: | Background Since atherogenesis is related to oxidative stress, our objective was to study the association of oxidative stress markers with the vascular recurrence in non-cardioembolic stroke. Methods Atherosclerotic and oxidative stress markers were evaluated on admission, in 477 patients suffering from a first non-cardioembolic stroke. Patients were followed at 6 and 12 months after inclusion, recording cardiovascular events. As markers of endothelial oxidative stress we used oxidized LDL, Cu/Zn superoxide dismutase and 8-OH deoxiguanosine. 136 patients were being treated with statins at the moment of serum samples acquisition. Results Patients who suffered vascular recurrence or vascular-origin death had higher levels of 8-OHDG (40.06±24.70vs33.11±15.18;p=0.003). We also found associations between vascular recurrence or vascular origin death and Cu/ZnSOD (OR,1.02; 95%CI,1.00-1.03;p=0.0001) and 8-OHDG (OR,1.12;95%CI,1.08-1.16;p Conclusions Specific oxidative stress markers were found to be markers of atherosclerosis plaque types and vascular recurrence in non-statins treated patients at admission. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|