Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men

Autor: John P. Forman, Alan J. Flint, Aedin Cassidy, Monica L. Bertoia, Stephanie E. Chiuve, Eric B. Rimm
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Heart disease
Myocardial Infarction
Medicine (miscellaneous)
heart disease
Disease
Brain Ischemia
Cohort Studies
Anthocyanins
Coronary artery disease
0302 clinical medicine
Risk Factors
Prospective Studies
Myocardial infarction
Stroke
Aged
80 and over
2. Zero hunger
Nutrition and Dietetics
Medical record
food and beverages
Men
flavanones
Middle Aged
anthocyanins
stroke
3. Good health
Flavanones
Diet
Healthy
Adult
medicine.medical_specialty
Health Personnel
men
030209 endocrinology & metabolism
Lower risk
03 medical and health sciences
SDG 3 - Good Health and Well-being
Internal medicine
medicine
Humans
Aged
Flavonoids
030109 nutrition & dietetics
business.industry
Polyphenols
Feeding Behavior
Cardiovascular Disease Risk
medicine.disease
United States
Surgery
Clinical trial
Fruit
flavonoids
Patient Compliance
Self Report
business
Follow-Up Studies
Zdroj: The American Journal of Clinical Nutrition
Cassidy, A, Bertoia, M, Chiuve, S, Flint, A, Forman, J & Rimm, E B 2016, ' Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men ', American Journal of Clinical Nutrition, vol. 104, no. 3, pp. 587-594 . https://doi.org/10.3945/ajcn.116.133132
ISSN: 0002-9165
DOI: 10.3945/ajcn.116.133132
Popis: Background: Although increased fruit intake reduces cardiovascular disease (CVD) risk, which fruits are most beneficial and what key constituents are responsible are unclear. Habitual intakes of flavonoids, specifically anthocyanins and flavanones, in which .90% of habitual intake is derived from fruit, are associated with decreased CVD risk in women, but associations in men are largely unknown. Objective: We examined the relation between habitual anthocyanin and flavanone intake and coronary artery disease and stroke in the Health Professionals Follow-Up Study. Design: We followed 43,880 healthy men who had no prior diagnosed CVD or cancer. Flavonoid intake was calculated with the use of validated food-frequency questionnaires. Results: During 24 y of follow-up, 4046 myocardial infarction (MI) and 1572 stroke cases were confirmed by medical records. Although higher anthocyanin intake was not associated with total or fatal MI risk, after multivariate adjustment an inverse association with nonfatal MI was observed (HR: 0.87; 95% CI: 0.75, 1.00; P = 0.04; P- Trend = 0.098); this association was stronger in normotensive participants (HR: 0.81; 95% CI: 0.69, 0.96; P-interaction = 0.03). Anthocyanin intake was not associated with stroke risk. Although flavanone intake was not associated with MI or total stroke risk, higher intake was associated with a lower risk of ischemic stroke (HR: 0.78; 95% CI: 0.62, 0.97; P = 0.03, P- Trend = 0.059), with the greatest magnitude in participants aged $65 y (P-interaction = 0.04). Conclusions: Higher intakes of fruit-based flavonoids were associated with a lower risk of nonfatal MI and ischemic stroke in men. Mechanistic studies and clinical trials are needed to unravel the differential benefits of anthocyanin- And flavanone-rich foods on cardiovascular health. Am J Clin Nutr 2016;104:587-94.
Databáze: OpenAIRE
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