General Functioning in Patients With First-Episode Psychosis After the First 18 Months of Treatment
| Autor: | Ana Koricancic Makar, Dina Bošnjak Kuharić, Drazenka Ostojic, Ivana Kekin, Zarko Bajic, Martina Rojnic Kuzman, Maja Zivkovic, Zoran Madzarac, Porin Makarić, Ante Silić |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Psychosis Time Factors medicine.medical_treatment Global Assessment of Functioning Neuropsychological Tests Ordinal regression Young Adult 03 medical and health sciences Cognition Sex Factors 0302 clinical medicine medicine Humans Pharmacology (medical) In patient Longitudinal Studies Antipsychotic business.industry medicine.disease Combined Modality Therapy 030227 psychiatry Psychotherapy Psychosocial Functioning Psychiatry and Mental health Treatment Outcome Schizophrenia first-episode psychosis treatment functioning neurocognitive symptoms Psychotherapy Group Female Schizophrenic Psychology Verbal memory business Psychosocial Neurocognitive 030217 neurology & neurosurgery Antipsychotic Agents Clinical psychology |
| Zdroj: | Journal of Clinical Psychopharmacology. 40:366-372 |
| ISSN: | 1533-712X 0271-0749 |
| Popis: | Background One of the main goals in the treatment of first-episode psychosis (FEP) is achieving functional remission. This study aims to analyze whether initial neurocognitive status and the use of specific pharmacological and psychosocial treatment options in FEP can predict general functioning after 18 months of treatment. Methods We conducted a longitudinal naturalistic study with a sample of 129 patients with FEP treated at 2 Croatian psychiatric clinics from 2016until 2018. Ordinal regression was used to predict the global level of functioning assessed with the Global Assessment of Functioning scale (GAF) at the 18th month of treatment from the baseline symptoms (assessed with a set of neurocognitive tests) and different treatment options. Results Higher score on GAF at the 18th month was significantly predicted by female sex, better baseline verbal memory and GAF scores, and the type of treatment. Group multimodal psychosocial treatment, antipsychotic polytherapy, and not being treated with sedatives at baseline predicted better GAF scores at follow-up. In the exploratory analysis, taking sedatives in the final assessment and being rehospitalized due to relapse predicted worse GAF scores at the end of follow-up. Conclusions Although baseline neurocognitive features and baseline general functioning seem to influence the overall long-term functioning of persons with FEP, addition of a multimodal group psychosocial treatment program and appropriate medication seem to be equally important for improving the patients' level of functioning after the FEP. |
| Databáze: | OpenAIRE |
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