Seasonal activity, vector relationships and genetic analysis of mosquito-borne Stratford virus

Autor: Cameron E. Webb, Cheryl S. Toi, John Clancy, John Haniotis, Stephen L. Doggett
Rok vydání: 2016
Předmět:
0301 basic medicine
RNA viruses
lcsh:Medicine
Marine and Aquatic Sciences
Disease Vectors
Geographical Regions
Pathology and Laboratory Medicine
Genetic analysis
Mosquitoes
Geographical Locations
0302 clinical medicine
Abundance (ecology)
Aedes
Medicine and Health Sciences
Stratford virus
lcsh:Science
Phylogeny
Coastal Regions
Multidisciplinary
biology
Geography
Insects
Infectious Diseases
Medical Microbiology
Viral Pathogens
Viruses
Engineering and Technology
Seasons
Viral Vectors
Pathogens
Research Article
Freshwater Environments
Arthropoda
030231 tropical medicine
Oceania
Zoology
Mosquito Vectors
Microbiology
Virus
03 medical and health sciences
Virology
Animals
Humans
Prototypes
Microbial Pathogens
Genetic diversity
Flaviviruses
lcsh:R
Ecology and Environmental Sciences
Organisms
Australia
Outbreak
Biology and Life Sciences
Aquatic Environments
Bodies of Water
biology.organism_classification
Invertebrates
Insect Vectors
Species Interactions
Lakes
Regional Geography
030104 developmental biology
Technology Development
Vector (epidemiology)
People and Places
Earth Sciences
lcsh:Q
Viral Transmission and Infection
Arboviruses
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0173105 (2017)
ISSN: 1932-6203
Popis: There are many gaps to be filled in our understanding of mosquito-borne viruses, their relationships with vectors and reservoir hosts, and the environmental drivers of seasonal activity. Stratford virus (STRV) belongs to the genus Flavivirus and has been isolated from mosquitoes and infected humans in Australia but little is known of its vector and reservoir host associations. A total of 43 isolates of STRV from mosquitoes collected in New South Wales between 1995 and 2013 was examined to determine the genetic diversity between virus isolates and their relationship with mosquito species. The virus was isolated from six mosquito species; Aedes aculeatus, Aedes alternans, Aedes notoscriptus, Aedes procax, Aedes vigilax, and Anopheles annulipes. While there were distinct differences in temporal and spatial activity of STRV, with peaks of activity in 2006, 2010 and 2013, a sequence homology of 95.9%-98.4% was found between isolates and the 1961 STRV prototype with 96.2%-100% identified among isolates. Temporal differences but no apparent nucleotide divergence by mosquito species or geographic location was evident. The result suggests the virus is geographically widespread in NSW (albeit only from coastal regions) and increased local STRV activity is likely to be driven by reservoir host factors and local environmental conditions influencing vector abundance. While STRV may not currently be associated with major outbreaks of human disease, with the potential for urbanisation and climate change to increase mosquito-borne disease risks, and the possibility of genomic changes which could produce pathogenic strains, understanding the drivers of STRV activity may assist the development of strategic response to public health risks posed by zoonotic flaviviruses in Australia.
Databáze: OpenAIRE
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