Comparison of QuantiFERON-TB Gold and the tuberculin skin test for detecting previous tuberculosis infection evaluated by chest CT findings in Japanese rheumatoid arthritis patients
| Autor: | Shogo Banno, Ryzo Ueda, Maiko Watanabe, Yoshihito Hayami, Shinji Maeda, Tomoyo Maeda, Taio Naniwa, Shigeki Sato |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Tuberculosis Prednisolone Tuberculin Arthritis Enzyme-Linked Immunosorbent Assay Gastroenterology QuantiFERON Arthritis Rheumatoid Interferon-gamma Japan Tuberculosis diagnosis Internal medicine medicine Humans Pharmacology (medical) Aged Bacteriological Techniques Tuberculin Test business.industry Middle Aged bacterial infections and mycoses medicine.disease Surgery Methotrexate Infectious Diseases Antirheumatic Agents Rheumatoid arthritis BCG Vaccine Female Radiography Thoracic business BCG vaccine medicine.drug |
| Zdroj: | Journal of Infection and Chemotherapy. 17:842-848 |
| ISSN: | 1341-321X |
| DOI: | 10.1007/s10156-011-0250-1 |
| Popis: | The aim of the study was to compare the usefulness of the QuantiFERON-TB Gold (QFT-2G) with that of the tuberculin skin test (TST) for detecting previous infection of tuberculosis (TB) in Japanese rheumatoid arthritis (RA) patients. Before receiving biologic therapy, 97 RA patients were divided into two groups based on their chest computed tomography (CT) findings: the TB past infection group (n = 48), with old inflammatory changes due to prior pulmonary TB; and the non-TB infection group (n = 49), without such findings. The QFT-2G was not affected by methotrexate or prednisolone. Indeterminate results with a positive control had a low incidence (5.2%). A positive QFT-2G for the TB past infection group at cutoffs of 0.35 and 0.1 IU/ml (intermediate range) was seen in 5.8% and 20.8%, respectively. A TST >20 mm was significantly higher in the non-TB infection group (31%) than in the TB past infection group (13%). The correlation between the QFT-2G and TST was poor among all patients. Disagreement between these tests in the non-TB infection group was caused by the false-positive TST induced by previous Bacillus Calmette-Guerin (BCG) vaccination. Only 12 (12.4%) of 97 patients had a positive QFT-2G (≥0.1 IU/ml) and a negative TST ( |
| Databáze: | OpenAIRE |
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