Computational modeling of cardiac fatty acid uptake and utilization
| Autor: | Musters, M.W.J.M., Bassingthwaighte, J.B., Panday, V., Riel, van, N.A.W., Vusse, van der, G.J., Bittar, E.E. |
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| Přispěvatelé: | Computational Biology, Control Systems, Experimental Vascular Medicine, ACS - Microcirculation, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism |
| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Lipobiology, 173-221 STARTPAGE=173;ENDPAGE=221;TITLE=Lipobiology |
| DOI: | 10.1016/s1569-2558(03)33010-3 |
| Popis: | Publisher Summary This chapter highlights how computer modeling helps in understanding the processes of uptake of fatty acids (FAs), the main source of energy under normal conditions in heart. FA transport from the blood into the heart muscle cells (cardiomyocytes) is diagrammed in a general way in the chapter. A computer model has the advantage that it takes relatively little time to get results. In general, physiological experiments consume a lot of time due to preparation and conduction. As a consequence, computer modeling is in general cheaper. An advantage of modeling is the integration of heterologous information. In most cases, a physiological model contains data of different sources. Therefore, a computer model provides a quantitatively consistent description and reveals if the physiological theory or data of this system is ill defined. The chapter also provides the physiological background and modeling approach, which describes the physiological conditions in mathematical equations. |
| Databáze: | OpenAIRE |
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