Outcomes and Prognostic Factors in a Large Cohort of Hospitalized Cancer Patients With COVID-19
| Autor: | Driele Peixoto, Renata Colombo Bonadio, Juliana Pereira, Odeli Nicole Encinas Sejas, Camilla Hoff, Vanderson Rocha, Gabriel Y. Watarai, Veruska Menegatti Anastacio, Camila Motta Venchiarutti Moniz, Lorena Teixeira Frasson, Edson Abdala, Raquel Keiko de Luca Ito, Guilherme Nader Marta, Maria Del Pilar Estevez-Diz, Maria Cecilia Mathias Machado, Paulo M. Hoff, Ulysses Ribeiro |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
2019-20 coronavirus outbreak medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) MEDLINE 03 medical and health sciences 0302 clinical medicine Neoplasms Internal medicine Cancer-Related Complications Humans Medicine 030212 general & internal medicine Aged SARS-CoV-2 business.industry COVID-19 Neoplasms therapy Cancer ORIGINAL REPORTS Prognosis medicine.disease Large cohort Hospitalization Increased risk Oncology 030220 oncology & carcinogenesis business |
| Zdroj: | JCO Global Oncology |
| ISSN: | 2687-8941 |
| Popis: | PURPOSE Patients with cancer are at increased risk for unfavorable outcomes from COVID-19. Knowledge about the outcome determinants of severe acute respiratory syndrome coronavirus 2 infection in this population is essential for risk stratification and definition of appropriate management. Our objective was to evaluate prognostic factors for all-cause mortality in patients diagnosed with both cancer and COVID-19. METHODS All consecutive patients with cancer hospitalized at our institution with COVID-19 were included. Electronic medical records were reviewed for clinical and laboratory characteristics potentially associated with outcomes. RESULTS Five hundred seventy-six consecutive patients with cancer and COVID-19 were included in the present study. An overall in-hospital mortality rate of 49.3% was demonstrated. Clinical factors associated with increased risk of death because of COVID-19 were age over 65 years, Eastern Cooperative Oncology Group performance status > 0 zero, best supportive care, primary lung cancer, and the presence of lung metastases. Laboratory findings associated with a higher risk of unfavorable outcomes were neutrophilia, lymphopenia, and elevated levels of D-dimer, creatinine, C-reactive protein, or AST. CONCLUSION A high mortality rate in patients with cancer who were diagnosed with COVID-19 was demonstrated in the present study, emphasizing the need for close surveillance in this group of patients, especially in those with unfavorable prognostic characteristics. |
| Databáze: | OpenAIRE |
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