Bivalent Influenza Vaccine in Children with Cancer
| Autor: | Ciro Valent Sumaya, Philip A. Brunell, Thomas E. Williams |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Cancer chemotherapy
Adolescent Lymphoma Dose Influenza vaccine Antibodies Viral Placebo Bivalent (genetics) Neuroblastoma Vaccine administration Immune system Antigen Humans Immunology and Allergy Medicine Child Leukemia biology business.industry Retinoblastoma Sarcoma Hodgkin Disease Vaccination Infectious Diseases Influenza Vaccines Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Antibody business |
| Zdroj: | Journal of Infectious Diseases. 136:S656-S660 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/136.supplement_3.s656 |
| Popis: | Although it has been recommended that children with malignant diseases be immunized against influenza, few data are available to indicate the immune response or reactions that might be expected from this group. In this study, 46 children with malignant diseases received varying dosages of killed split or whole bivalent (A/New Jersey/76 and A/Victoria/75) influenza vaccine or a placebo by the intramuscular route. Two doses were administered four weeks apart. The children were receiving standard cancer chemotherapy regimens of the Children's Cancer Study Group. The response to immunization in the children with malignant diseases was similar to that found in normal children who received aliquots of the same antigen preparations as killed monovalent A/New Jersey/76 vaccine. Reactions after vaccine administration were minimal. It is concluded that the dose of influenza antigen in the vaccine recommended for normal children would appear to be appropriate for children with malignant diseases. In addition to immunization against A/New Jersey/76 it has been recommended that the children with malignant diseases receive antigen preparations of other prevalent influenzal strains. |
| Databáze: | OpenAIRE |
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