Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns

Autor: Joel L. Voss, Mehmet E. Dokucu, Anthony J. Ryals, Frank J. Penedo, Pei An Shih, David Cella, Kathryn I. Alpert, Lynne I. Wagner, Alexandra C. Apple, Lei Wang
Rok vydání: 2017
Předmět:
Adult
Oncology
medicine.medical_specialty
Cognitive Neuroscience
Breast Neoplasms
NIH Toolbox
Neuropsychological Tests
lcsh:Computer applications to medicine. Medical informatics
Hippocampus
Brain mapping
lcsh:RC346-429
Young Adult
NIH toolbox
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Image Processing
Computer-Assisted
medicine
Humans
Radiology
Nuclear Medicine and imaging
Survivors
Effects of sleep deprivation on cognitive performance
Young adult
Episodic memory
lcsh:Neurology. Diseases of the nervous system
Analysis of Variance
Brain Mapping
Memory Disorders
Regular Article
Cognition
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Neurocognitive
Neurology
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
lcsh:R858-859.7
Female
Self Report
Neurology (clinical)
Cognition Disorders
Psychology
Cancer-related cognitive impairment (CRCI)
030217 neurology & neurosurgery
Clinical psychology
Zdroj: NeuroImage : Clinical
NeuroImage: Clinical, Vol 14, Iss C, Pp 685-691 (2017)
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2017.03.004
Popis: Cancer survivors have lingering cognitive problems, however the anatomical basis for these problems has yet to be fully elucidated. Clinical studies as well as animal models of chemotherapy have pinpointed cell and volume loss to the hippocampus, however, few studies have performed shape analysis of the hippocampus on cancer survivors. This study used high-dimensional deformation mapping analysis to test whether localized hippocampal deformation differs in breast cancer survivors who received adjuvant chemotherapy coupled with hormone blockade therapy, and if deformation was related to subjective self-reported concerns and cognitive performance. 3 T MRI images were acquired from 16 pre-menopausal breast cancer survivors and 18 healthy controls without a history of cancer. Breast cancer survivors had undergone chemotherapy within the eighteen months prior to the study, and were receiving estrogen-blockade therapy at the time of the study. Automated high-dimensional deformation mapping was used to compare localized hippocampal deformation differences between groups. Self-reported subjective concerns were assessed using Neuro-QOL Cognitive Function assessment, whereas cognitive performance was evaluated using the NIH Toolbox Cognition Battery. Relative to healthy controls, cancer survivors showed significantly more inward hippocampal deformation, worse self-reported cognitive functioning, and inferior episodic memory test score. This study is the first of its kind to examine the relationship between hippocampal deformity and cognitive impairment in cancer survivors.
Highlights • Cancer survivors demonstrated significant inward hippocampal deformation. • Survivors self-reported worse cognitive functioning. • Survivors performed worse than controls on a test of episodic memory.
Databáze: OpenAIRE
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