Cystatin C, beta-2-microglobulin and beta-trace protein in pre-eclampsia
| Autor: | Helena Strevens, Anders Grubb, Veronica Lindström, Karl Kristensen, Søren Blirup-Jensen, Christopher W. Schmidt, Dag Wide-Swensson |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy Trimester Third Renal function Preeclampsia chemistry.chemical_compound Pre-Eclampsia Predictive Value of Tests Pregnancy Internal medicine Blood plasma medicine Humans Cystatin C reproductive and urinary physiology Creatinine Eclampsia biology business.industry Beta-2 microglobulin Obstetrics and Gynecology General Medicine Blood Proteins medicine.disease Blood proteins Cystatins female genital diseases and pregnancy complications Lipocalins Intramolecular Oxidoreductases Endocrinology chemistry ROC Curve Case-Control Studies biology.protein Female business beta 2-Microglobulin Biomarkers |
| Zdroj: | Acta obstetricia et gynecologica Scandinavica. 86(8) |
| ISSN: | 0001-6349 |
| Popis: | An altered renal function is an essential component of the patho-physiology of pre-eclampsia. The plasma levels of low molecular mass proteins, e.g. beta-trace protein, beta-2-microglobulin and cystatin C, are increased in the third trimester of normal pregnancy. The plasma levels of cystatin C and beta-2-microglobulin are further increased in pre-eclampsia, and the cystatin C level has been reported to be a reliable marker for the disease. The aim of this investigation was to study the plasma levels of beta-trace protein, beta-2-microglobulin and cystatin C in pre-eclampsia, and to determine the diagnostic performance of these proteins compared to that of urate and creatinine.A case-control study of 57 women diagnosed with pre-eclampsia, and 218 healthy women with uncomplicated singleton pregnancies in the third trimester. Women in the catchment area of Lund, Sweden, were included during an 18-month period from October 2003 to April 2005. Venous blood samples were drawn upon inclusion when diagnosis was made. The maternal plasma concentrations of the 3 proteins were analysed by automated particle-enhanced immunoturbidimetric assays.The plasma levels of the 3 proteins were significantly higher in the third trimester of pre-eclamptic patients compared to healthy pregnant women in the third trimester. The upper reference limits (parametric 97.5 percentile) were 2.57 mg/l for beta-2-microglobulin, 0.72 mg/l for beta-trace protein and 1.37 mg/l for cystatin C. ROC analysis showed similar diagnostic performance for the 3 proteins, with beta-trace protein displaying the best diagnostic performance of all the analytes.In this study, the maternal plasma levels of beta2-microglobulin, beta-trace protein and cystatin C were all significantly elevated in pre-eclampsia compared to those of healthy pregnant women, and displayed similar diagnostic performance for diagnosing pre-eclampsia. The results indicate that low molecular mass proteins are useful as markers of renal impairment in pre-eclampsia. |
| Databáze: | OpenAIRE |
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