Using Rate of Acid Neutralization to Characterize Aluminum Phosphate Adjuvant

Autor:	Stanley L. Hem, Clifford T. Johnston, Dongping Jiang
Rok vydání:	2003
Předmět:	chemistry.chemical_classification Molar Time Factors Chromatography medicine.medical_treatment Proteins Pharmaceutical Science Aluminum Hydroxide General Medicine Hydrogen-Ion Concentration Neutralization Phosphates chemistry.chemical_compound Enzyme Adsorption Adjuvants Immunologic chemistry medicine Chemical Precipitation Aluminium phosphate Surface charge Lysozyme Adjuvant
Zdroj:	Pharmaceutical Development and Technology. 8:349-356
ISSN:	1097-9867 1083-7450
DOI:	10.1081/pdt-120024688
Popis:	Five aluminum phosphate adjuvants having P/Al molar ratios ranging from 0.74 to 0.26 were prepared. The adjuvants were characterized by both protein adsorptive capacity and rate of acid neutralization at pH 2.25, 25 degrees C. The protein adsorptive capacity was not a useful parameter to compare the initial properties of the adjuvants, as differences in surface charge of the adjuvants required the use of different proteins. In contrast, the rate of acid neutralization allowed a comparison of the freshly precipitated adjuvants and revealed that the rate of acid neutralization was directly related to the P/Al molar ratio. The protein adsorptive capacity decreased slightly during 39 weeks of aging at room temperature. The changes in the rate of acid neutralization were much greater and indicated that a P/Al molar ratio of at least 0.5 was required to minimize the aging of the adjuvants. Thus, the rate of acid neutralization was found to be the most sensitive parameter to characterize aluminum phosphate adjuvants.
Databáze:	OpenAIRE
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