| Autor: |
Jo Fen Liu, Timothy R. Rebbeck, Brian E. Henderson, Vincent Khoo, Lynne T. O'Brien, Anna M. Ray, Klara Stefflova, Ethan M. Lange, Joanne L. Dickinson, Shannon K. McDonnell, Sarah J Lewis, Amit Joshi, Thilo Dörk, Jyotsna Batra, Yong-Jie Lu, Manuel Luedeke, Rosemary A. Wilkinson, Michelle Guy, C. R. J. Woodhouse, David E. Neal, Christopher A. Haiman, Gianluca Severi, Liesel M. FitzGerald, Audrey Ardern-Jones, Douglas F. Easton, Erika M. Kwon, Colin Cooper, Dallas R. English, Kathleen A. Cooney, Daniel Leongamornlert, Graham G. Giles, Loic Le Marchand, Laurence N. Kolonel, C. Slavov, Daniel J. Schaid, Ahva Shahabi, Suzanne K. Chambers, Teuvo L.J. Tammela, Jong Y. Park, Johanna Schleutker, Robert Huddart, Melissa C. Southey, Sue A. Ingles, Tim Christmas, Judith A. Clements, Mary-Anne Kedda, Malgorzata Tymrakiewicz, David P. Dearnaley, Radka Kaneva, Edward J. Saunders, Thomas A. Sellers, Janet L. Stanford, Anssi Auvinen, Alan Thompson, Jonathan J. Morrison, Guangwen Cao, Amanda L. Hall, Humera Khan, Pierre Hutter, Stephen M. Edwards, Esther M. John, Emma J. Sawyer, Angela Cox, Lisa A. Cannon-Albright, Tiina Wahlfors, Pierre O. Chappuis, Stephen N. Thibodeau, Freddie C. Hamdy, Elaine A. Ostrander, Hong Wei Zhang, Nicholas Van As, John L. Hopper, Walther Vogel, Amanda B. Spurdle, Jürgen Serth, Joanne F. Aitken, Chris Ogden, Atanaska Mitkova, Felicity Lose, Zsofia Kote-Jarai, Elizabeth Page, Christiane Maier, Joseph S. Koopmeiners, William D. Foulkes, Kenneth Muir, Alan Horwich, Danielle M. Karyadi, Chris Parker, Briony Patterson, Julio M. Pow-Sang, Robert A. Gardiner, Ali Amin Al Olama, Mariana C. Stern, Roman Corral, Maurice P. Zeegers, Andrea M. Polanowski, Artitaya Lophatananon, Rosalind A. Eeles, Andreas Meyer, J. M. Farnham, Jenny L Donovan |
| Přispěvatelé: |
Complexe Genetica, Populatie Genetica, RS: NUTRIM - R4 - Gene-environment interaction |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Nature Genetics, 41(10), 1116-21. Nature Publishing Group |
| ISSN: |
1546-1718
1061-4036 |
| Popis: |
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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