Plasma levels of rotigotine and the reversal of motor deficits in MPTP-treated primates
| Autor: | Alexander Breidenbach, Sarah Rose, K. Stockwell, Michael F. Jackson, Dieter Scheller, Peter Jenner, Lance A. Smith |
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| Rok vydání: | 2007 |
| Předmět: |
Agonist
Tetrahydronaphthalenes medicine.drug_class Injections Subcutaneous Pulsatile flow Thiophenes Hyperkinesis Motor Activity Pharmacology chemistry.chemical_compound Dopamine receptor D3 Stereotypy Animals Medicine Dose-Response Relationship Drug business.industry MPTP MPTP Poisoning Callithrix Rotigotine Psychiatry and Mental health Regimen chemistry Anesthesia Female Stereotyped Behavior medicine.symptom business medicine.drug Blood sampling |
| Zdroj: | Behavioural Pharmacology. 18:155-160 |
| ISSN: | 0955-8810 |
| DOI: | 10.1097/fbp.0b013e3280ebb400 |
| Popis: | Rotigotine is a nonergolinic dopamine D3/D2/D1-receptor agonist used clinically for the treatment of Parkinson's disease. This study aimed to determine the relationship between peak antiparkinsonian activity and drug plasma levels after administration of rotigotine to 1-methyl-4-phenyl-1,2,3,6-tetrahydropytidine-treated primates. Using single subcutaneous injections of rotigotine and blood sampling at two subsequent time points, the relationship between improvement in motor activity and plasma rotigotine level was evaluated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropytidine-treated common marmosets. Rotigotine (0.01875-0.3 mg/kg subcutaneously) produced an increase in locomotor activity even at the lowest dose tested. Total increase in motor activity and duration of drug effect were dose related. Motor disability was similarly improved by rotigotine in a dose-dependent manner. At the highest doses, hyperactivity and stereotypy were observed. Plasma concentrations of rotigotine were linearly related to dose over dosage range employed, but not to behavioral response. Results show that pulsatile administration of rotigotine effectively normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropytidine-treated marmosets. Although dose and plasma concentrations of rotigotine are closely related, drug effects in the brain measured as locomotion and improvement of disability dissociate from plasma levels. Plasma levels corresponding to the optimal dose range (0.01875-0.075 mg/kg) will guide a continuous administration regimen of rotigotine in a subsequent study using the same experimental model of Parkinson's disease. |
| Databáze: | OpenAIRE |
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