Liver Iron Retention Estimated from Utilization of Oral and Intravenous Radioiron in Various Anemias and Hemochromatosis in Humans
| Autor: | Richard van Wijk, Annelies J. Van Vuren, Joannes J.M. Marx, Eduard J. van Beers |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Administration Oral lcsh:Chemistry 0302 clinical medicine lcsh:QH301-705.5 iron 2 Spectroscopy iron deficiency 5 Iron Radioisotopes Anemia Iron-Deficiency Chemistry Transferrin General Medicine Iron deficiency Middle Aged Computer Science Applications medicine.anatomical_structure Liver 030220 oncology & carcinogenesis Hereditary hemochromatosis hereditary anemia 4 Administration Intravenous Female Hemochromatosis Adult medicine.medical_specialty Adolescent Serum Albumin Human Anemia Hemolytic Congenital Catalysis Article Inorganic Chemistry 03 medical and health sciences Young Adult Internal medicine medicine Liver iron Humans In patient NTBI 3 Physical and Theoretical Chemistry Molecular Biology Aged Red Cell Organic Chemistry hemochromatosis 1 Albumin medicine.disease Red blood cell 030104 developmental biology Endocrinology lcsh:Biology (General) lcsh:QD1-999 Case-Control Studies |
| Zdroj: | International Journal of Molecular Sciences Volume 21 Issue 3 International Journal of Molecular Sciences, Vol 21, Iss 3, p 1077 (2020) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21031077 |
| Popis: | Patients with hereditary hemochromatosis and non-transfusion-dependent hereditary anemia develop predominantly liver iron-overload. We present a unique method allowing quantification of liver iron retention in humans during first-pass of 59Fe-labeled iron through the portal system, using standard ferrokinetic techniques measuring red cell iron uptake after oral and intravenous 59Fe administration. We present data from patients with iron deficiency (ID N = 47), hereditary hemochromatosis (HH N = 121) and non-transfusion-dependent hereditary anemia (HA N = 40). Mean mucosal iron uptake and mucosal iron transfer (± SD) were elevated in patients with HH (59 ± 18%, 80 ± 15% respectively), HA (65 ± 17%, 74 ± 18%) and ID (84 ± 14%, 94 ± 6%) compared to healthy controls (43 ± 19%, 64 ± 18%) (p < 0.05) resulting in increased iron retention after 14 days compared to healthy controls in all groups (p < 0.01). The fraction of retained iron utilized for red cell production was 0.37 ± 0.17 in untreated HA, 0.55 ± 0.20 in untreated HH and 0.99 ± 0.22 in ID (p < 0.01). Interestingly, compared to red blood cell iron utilization after oral iron administration, red blood cell iron utilization was higher after injection of transferrin-bound iron in HA and HH. Liver iron retention was considerably higher in HH and HA compared to ID. We hypothesize that albumin serves as a scavenger of absorbed Fe(II) for delivering albumin-bound Fe(III) to hepatocytes. |
| Databáze: | OpenAIRE |
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