Pregnancy attributable to interaction between tetracycline and oral contraceptives
| Autor: | G M Shenfield, J F Bacon |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy Breakthrough bleeding medicine Humans Drug Interactions Sinusitis General Environmental Science Gynecology Obstetrics business.industry General Engineering General Medicine Tetracycline Bleed medicine.disease Diarrhea Family planning Vomiting General Earth and Planetary Sciences Female medicine.symptom business Developed country Research Article Contraceptives Oral |
| Zdroj: | BMJ. 280:293-293 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.280.6210.293 |
| Popis: | Various drugs, including antibiotics, may be responsible for contraceptive failure and breakthrough bleeding in oral contraceptive (OC) users. A case history is reported of a woman who took OCs for 4 years without a problem. On October 16, 1978 she had a normal withdrawal bleed, and on October 20 she started the next course of Microgynon and also a 5-day course of tetracyline 500 mg 6 hourly for 3 days and also 250 mg 6 hourly for 2 days for sinusitis. She completed the course on October 24. She did not fail to take her OC, had no diarrhea or vomiting but had only a very light 2-day withdrawal bleed on November 14 and 15, 1978. She continued to take her OC for another 2 months until seen at the family planning clinic on January 8, 1979. Her uterus was then the size of at least a 12-week pregnancy. This would have corresponded with a previous menstrual period on about October 15 and indicated that she must have ovulated either when she was taking the tetracycline or in the week after. Termination confirmed the clinical assessment of the duration of pregnancy. The time course of this history of an OC user who had no problems for 4 years suggests that the tetracycline contributed to the contraceptive failure. |
| Databáze: | OpenAIRE |
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