A Two-Dimensional Model of Potassium Signaling and Oscillatory Growth in a Biofilm
| Autor: | Garth Fisher, Arthur Prindle, Noah Ford, David L. Chopp |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology Chemistry General Mathematics General Neuroscience Immunology Biofilm Dimensional modeling Bacterial Physiological Phenomena Models Biological General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Computational Theory and Mathematics Biofilms 030220 oncology & carcinogenesis Potassium General Agricultural and Biological Sciences Biological system Bacillus subtilis Signal Transduction General Environmental Science |
| Zdroj: | Bulletin of Mathematical Biology. 83 |
| ISSN: | 1522-9602 0092-8240 |
| Popis: | Biofilms are complex communities of bacteria that exhibit a variety of collective behaviors. These behaviors improve their ability to survive in many different environments. One of these collective behaviors seen in Bacillus subtilis is the ability for starving cells to stop the growth of other cells using potassium signaling and voltage changes. This signaling produces an oscillatory growth pattern so that during periods of low growth the nutrients diffuse deeper into the biofilm and reach the nutrient-starved, interior regions of the biomass. In this paper, we develop a mathematical model to describe this oscillatory behavior, and we use this model to develop a two-dimensional simulation that reproduces many of the important features seen in the experimental data. This simulation allows us to examine the spatial patterning of the oscillatory behavior to better understand the relationships between the various regions of the biofilm. Studying the spatial components of the metabolic and voltage oscillations could allow for the development of new control techniques for biofilms with complex shapes. |
| Databáze: | OpenAIRE |
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