Are plant factors a missing link in the evolution of endemic Burkitt's lymphoma?
| Autor: | P. Kazembe, C. van den Bosch, C. Dziweni, L. Kadzamira, B. E. Griffin |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Herpesvirus 4 Human Malawi Cancer Research Adolescent Euphorbia tirucalli medicine.disease_cause Herpesviridae Virus immune system diseases hemic and lymphatic diseases Phorbol Esters medicine Humans Gammaherpesvirinae Child Cocarcinogenesis Plants Medicinal biology fungi food and beverages Plants medicine.disease biology.organism_classification Burkitt Lymphoma Endemic Burkitt's lymphoma Virology Epstein–Barr virus Lymphoma Oncology Child Preschool Immunology Female Virus Activation Viral disease Diterpenes Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1993.510 |
| Popis: | Burkitt's lymphoma, an Epstein-Barr virus (EBV)-associated non-Hodgkin's malignant lymphoma is endemic in an area of Africa known as the Lymphoma Belt. This zone is demarcated by climatic requirements of temperature and rainfall. EBV-activating plant factors are among several co-factors which have been proposed for the development of epidemic Burkitt's Lymphoma (eBL). The distribution of Euphorbia tirucalli, a plant which possesses EBV-activating substances and can induce the characteristic 8:14 translocation of eBL in EBV-infected lymphoblastic cell lines in vitro, conforms closely to the climatic requirements of the Lymphoma. This plant, other EBV-activating plants and plants of unknown EBV-activating status with medicinal uses, are found significantly more often at the homes of eBL patients in Malawi than in those of controls. The possible role of these plant factors in the pathogenesis of eBL and their routes of bodily access are discussed. It is postulated that the associations described in this paper provide support for the theory that EBV-activating plants are co-factors involved in the pathogenesis of some cases of eBL. |
| Databáze: | OpenAIRE |
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