A Single Dose, Randomized, Controlled Proof-Of-Mechanism Study of a Novel Vasopressin 1a Receptor Antagonist (RG7713) in High-Functioning Adults with Autism Spectrum Disorder
| Autor: | Lauren Boak, Omar Khwaja, Daniel Umbricht, Christophe Grundschober, James T. McCracken, Eric Hollander, Heidemarie Kletzl, Lisa Squassante, Marta del Valle Rubido, Frederick Shic, Jana Noeldeke, Lawrence Scahill, Paulo Fontoura |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Receptors Vasopressin Vasopressin medicine.medical_specialty Indoles Adolescent Autism Spectrum Disorder medicine.drug_class Pharmacology High functioning law.invention Young Adult 03 medical and health sciences Cognition 0302 clinical medicine Double-Blind Method Randomized controlled trial law medicine Humans Spiro Compounds Psychiatry Receptor Psychotropic Drugs Cross-Over Studies Mechanism (biology) Communication Middle Aged medicine.disease Receptor antagonist Crossover study Psychiatry and Mental health Treatment Outcome 030104 developmental biology Social Perception Autism spectrum disorder Original Article Corrigendum Psychology 030217 neurology & neurosurgery Preliminary Data |
| Zdroj: | Neuropsychopharmacology |
| ISSN: | 1740-634X 0893-133X 0147-4278 |
| DOI: | 10.1038/npp.2016.232 |
| Popis: | The core symptoms of autism spectrum disorder (ASD) include impaired social communication, repetitive behaviors, and restricted interests. No effective pharmacotherapy for these core deficits exists. Within the domain of social communication, the vasopressin system is implicated in social cognition and social signaling deficits of ASD, and represents a potential therapeutic target. We assessed the effects of a single 20 mg intravenous dose of the arginine vasopressin receptor 1A (V1a) antagonist, RG7713, on exploratory biomarkers (eye tracking), behavioral and clinical measures of social cognition and communication (affective speech recognition (ASR), reading the mind in the eyes, olfactory identification, scripted interaction), and safety and tolerability in a multicenter, randomized, double-blind, placebo-controlled, cross-over study of 19 high-functioning adult male subjects with DSM-IV Autistic Disorder (age 18–45 years; full scale IQ >70; ABC-Irritability subscale ⩽13). Eye-tracking showed an increase in biological motion orienting preference with RG7713 (ES=0.8, p=0.047) and a non-significant improvement in the composite score (ES=0.2, p=0.29). RG7713 reduced ability to detect lust (ES=−0.8, p=0.03) and fear (ES=−0.7, p=0.07) in ASR. However, when all eight individual emotion subscales were combined into an overall ASR performance score, the reduction was non-significant (ES=−0.1, p=0.59). Thirteen adverse events were reported in 10 subjects; all were of mild (11/13) or moderate (2/13) severity. Although interpretation should be cautious due to multiple comparisons and small sample size, these results provide preliminary evidence from experimental and behavioral biomarkers, that blockade of the V1a receptor may improve social communication in adults with high-functioning ASD. ClinicalTrials.gov identifier: NCT01474278 A Study of RO5028442 in Adult Male High-Functioning Autistic Patients. Available at: https://clinicaltrials.gov/ct2/show/NCT01474278 |
| Databáze: | OpenAIRE |
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