Evidence for an Elevation in Serum Interleukin-2 and Tumor Necrosis Factor-α Levels Before the Clinical Manifestations of Preeclampsia
| Autor: | Hidenori Nishina, Yuji Taketani, Shiro Kozuma, Tomoyuki Fujii, Yoko Hamai, Takahiro Yamashita, Yasuyo Mikami |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Interleukin 2 medicine.medical_specialty medicine.medical_treatment Immunology Enzyme-Linked Immunosorbent Assay Gastroenterology Preeclampsia Pathogenesis Pre-Eclampsia Pregnancy Internal medicine medicine Humans Immunology and Allergy Prospective Studies Tumor necrosis factor α reproductive and urinary physiology Tumor Necrosis Factor-alpha business.industry Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications Pregnancy Trimester First First trimester Endocrinology Cytokine Reproductive Medicine embryonic structures Interleukin-2 Female Tumor necrosis factor alpha business medicine.drug |
| Zdroj: | American Journal of Reproductive Immunology. 38:89-93 |
| ISSN: | 1046-7408 |
| Popis: | PROBLEM: The purpose of this study is to clarify whether the disruption of immune regulation occurs in early pregnancy before the clinical manifestations of preeclampsia. METHOD OF STUDY: The serum concentrations of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) were determined by using enzyme-linked immunoadsorbent assay (ELISA) in the first trimester of pregnancy in women who had preeclampsia develop after 28 weeks of pregnancy (preeclamptic group) and in women who completed pregnancy uneventfully (control group). RESULTS: Serum concentrations of both IL-2 and TNF-α in the first trimester of the preeclamptic group were significantly higher than those of the control group. CONCLUSIONS: That the perturbation of feto-maternal immune regulation may precede the clinical manifestations of preeclampsia, which may be of relevance in the development of preeclampsia, is suggested. |
| Databáze: | OpenAIRE |
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