Surviving the Rookie Virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2): The Immunopathology of a SARS-CoV2 Infection
| Autor: | Ching Ann Liu, Hong Meng Chuang, Kang Yun Lu, Sheng Feng Tsai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Middle East respiratory syndrome coronavirus
Biomedical Engineering lcsh:Medicine medicine.disease_cause Severe Acute Respiratory Syndrome Virus Immunopathology vaccine Case fatality rate medicine immunopathology Animals Humans skin and connective tissue diseases Coronavirus Inflammation Transplantation business.industry SARS-CoV-2 fungi lcsh:R COVID-19 Cell Biology medicine.disease Virology Review (Invited) body regions Cytokine release syndrome Severe acute respiratory syndrome-related coronavirus SARS-CoV2 Lymphocytopenia business Cytokine storm Coronavirus Infections Cytokine Release Syndrome |
| Zdroj: | Cell Transplantation, Vol 30 (2021) Cell Transplantation |
| ISSN: | 1555-3892 |
| Popis: | Until July 29th, the number of confirmed coronavirus (COVID-19) cases worldwide has risen to over 16 million, within which 655 k deaths. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) emerges as the 11th global pandemic disease, showing the highest infectivity and lowest infection fatality rate. In this review, we compare the immunopathology among SARS-CoV, Middle East respiratory syndrome coronavirus, and SARS-CoV2. SARS-CoV2 is similar to SARS-CoV; it can cause lymphocytopenia and a rising granulocyte count. Here we point out the human body and concentrated society make for an excellent incubator for virus evolution. Most research energies put into developing the SARS-CoV2 vaccine are trying to block virus infection. Sixty-five percent of severe patients die with multiple organ failure, inflammation, and cytokine storm, which indicates that the patient’s immune system maintains functionality. Finding a way to trigger the specific T cell subset and plasmablast in our body is the best shot to get away with SARS-CoV2. |
| Databáze: | OpenAIRE |
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