Foot gangrene in patients with end-stage renal disease: a case control study
| Autor: | Pierre Ronco, Parinaz Ghaffari, Mourad Boufi, H. Fessi, Michel Vayssairat, Eric Allaire |
|---|---|
| Přispěvatelé: | Thérapeutiques substitutives du coeur et des vaisseaux (TSCV), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Sauvant, Nicole |
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Hemodynamics 030204 cardiovascular system & hematology Amputation Surgical End stage renal disease Nephropathy Gangrene 03 medical and health sciences 0302 clinical medicine Renal Dialysis Diabetes mellitus Internal medicine medicine Humans 030212 general & internal medicine Aged business.industry Foot Case-control study Middle Aged medicine.disease Atherosclerosis Limb Salvage Survival Analysis 3. Good health Surgery Amputation Case-Control Studies Cardiology Quality of Life Kidney Failure Chronic Female Cardiology and Cardiovascular Medicine business Kidney disease |
| Zdroj: | Angiology Angiology, SAGE Publications, 2006, 57(3), pp.355-61 |
| ISSN: | 0003-3197 |
| Popis: | The prevalence of peripheral arterial disease (PAD) in patients with end-stage renal disease (ESRD) is high, with an annual risk of amputation estimated at 13%, and indications for limb revascularization in patients combining ESRD with stage IV PAD (foot gangrene) are still controversial. This case-controlled study compared survival, limb salvage, and quality of life in a group of patients hospitalized for foot gangrene according to their renal status (ESRD versus no renal insufficiency). All patients with ESRD hospitalized for foot gangrene (n=16) from 1996 to 2002 were compared with a control group with normal creatininemia (n=24) hospitalized for foot gangrene due to peripheral atherosclerotic arterial disease. The 2 groups were matched for age, sex ratio, and number with diabetes mellitus. After a mean follow-up of 467 ±410 days, patients with ESRD had a more severe prognosis as regards mortality (68.7% vs 12.5%, p=0.0005) and major amputation (31% versus 8%, p=0.09). The ESRD group was characterized by more frequent extensive arterial calcifications (16/16 vs 13/24, p=0.002), owing to a higher level of the calcium phosphorus product (3.54 ±1.2 vs 2.4 ±0.6, p=0.0023), and by impaired microcirculatory perfusion, as indicated by a lower oxygen pressure (TcPO2) (15.6 ±12 mm Hg vs 26 ±16, p=0.07). ESRD implies a poor prognosis in patients with stage IV peripheral arterial disease. |
| Databáze: | OpenAIRE |
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